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Potential causal effect of contact precautions and isolation on Clostridioides difficile infection in the hyperendemic setting: Interrupted time-series analyses before and after implementation
DC Field | Value | Language |
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dc.contributor.author | 송영구 | - |
dc.contributor.author | 이경화 | - |
dc.contributor.author | 이혜선 | - |
dc.contributor.author | 한상훈 | - |
dc.contributor.author | 이은화 | - |
dc.date.accessioned | 2023-11-07T07:40:29Z | - |
dc.date.available | 2023-11-07T07:40:29Z | - |
dc.date.issued | 2023-10 | - |
dc.identifier.issn | 1684-1182 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/196489 | - |
dc.description.abstract | Background: Recent studies disputed the effectiveness of efforts to comply with contact precautions and isolation (CPI) considering relatively low intra-hospital transmission rate of healthcare facility-associated Clostridioides difficile infection (HCFA-CDI). We evaluated the potential causal effect of CPI on HCFA-CDI occurrence by comparing the incidence rate (IR) for different time periods with and without CPI implementation. Methods: Long-term observational time-series data were separated into three periods (pre-CPI: January 2012-March 2016, CPI: April 2016-April 2021, post-CPI: May 2021-December 2022). CPI was suspended owing to the restriction of isolation rooms during the COVID-19 pandemic. We inferred potential causal outcomes by comparing predicted and observed IRs of HCFA-CDI using interrupted time-series analyses, including the Bayesian structural time-series or autoregressive integrated moving average (ARIMA) model in the R-language or SAS software. Results: The monthly observed IR (44.9/100,000 inpatient-days) during the CPI period was significantly lower than the predicted IR (90.8) (-50.6% relative effect, P = 0.001). However, the observed IR (52.3) during the post-CPI period was significantly higher than the predicted IR (39.1) (33.6%, P = 0.001). The HCFA-CDI IR decreased during CPI (-14.3, P < 0.001) and increased post-CPI (5.4, P < 0.001) in the multivariable ARIMA model, which controlled for antibiotic usage, handwashing with soap and water, and number of toxin tests. Conclusions: Various time-series models revealed that CPI implementation had a potential causal effect on the reduction of HCFA-CDI incidence. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English, Chinese | - |
dc.publisher | Elsevier for the Taiwan Society of Microbiology | - |
dc.relation.isPartOf | JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Bayes Theorem | - |
dc.subject.MESH | COVID-19* / epidemiology | - |
dc.subject.MESH | COVID-19* / prevention & control | - |
dc.subject.MESH | Clostridioides difficile* | - |
dc.subject.MESH | Clostridium Infections* / epidemiology | - |
dc.subject.MESH | Clostridium Infections* / prevention & control | - |
dc.subject.MESH | Cross Infection* / epidemiology | - |
dc.subject.MESH | Cross Infection* / prevention & control | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Pandemics | - |
dc.title | Potential causal effect of contact precautions and isolation on Clostridioides difficile infection in the hyperendemic setting: Interrupted time-series analyses before and after implementation | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Eun Hwa Lee | - |
dc.contributor.googleauthor | Hye Sun Lee | - |
dc.contributor.googleauthor | Kyoung Hwa Lee | - |
dc.contributor.googleauthor | Young Goo Song | - |
dc.contributor.googleauthor | Sang Hoon Han | - |
dc.identifier.doi | 10.1016/j.jmii.2023.06.003 | - |
dc.contributor.localId | A02037 | - |
dc.contributor.localId | A04620 | - |
dc.contributor.localId | A03312 | - |
dc.contributor.localId | A04286 | - |
dc.relation.journalcode | J01595 | - |
dc.identifier.eissn | 1995-9133 | - |
dc.identifier.pmid | 37380552 | - |
dc.subject.keyword | Clostridioides difficile | - |
dc.subject.keyword | Contact precaution | - |
dc.subject.keyword | Incidence | - |
dc.subject.keyword | Isolation | - |
dc.subject.keyword | Time-series analysis | - |
dc.contributor.alternativeName | Song, Young Goo | - |
dc.contributor.affiliatedAuthor | 송영구 | - |
dc.contributor.affiliatedAuthor | 이경화 | - |
dc.contributor.affiliatedAuthor | 이혜선 | - |
dc.contributor.affiliatedAuthor | 한상훈 | - |
dc.citation.volume | 56 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 1054 | - |
dc.citation.endPage | 1063 | - |
dc.identifier.bibliographicCitation | JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION, Vol.56(5) : 1054-1063, 2023-10 | - |
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