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Quantification of structural heterogeneity in H&E stained clear cell renal cell carcinoma using refractive index tomography

Authors
 Juyeon Park  ;  Su-Jin Shin  ;  Jeongwon Shin  ;  Ariel J Lee  ;  Moosung Lee  ;  Mahn Jae Lee  ;  Geon Kim  ;  Ji Eun Heo  ;  Kwang Suk Lee  ;  YongKeun Park 
Citation
 BIOMEDICAL OPTICS EXPRESS, Vol.14(3) : 1071-1081, 2023-02 
Journal Title
BIOMEDICAL OPTICS EXPRESS
Issue Date
2023-02
Abstract
Clear cell renal cell carcinoma (ccRCC) is a common histopathological subtype of renal cancer and is notorious for its poor prognosis. Its accurate diagnosis by histopathology, which relies on manual microscopic inspection of stained slides, is challenging. Here, we present a correlative approach to utilize stained images and refractive index (RI) tomography and demonstrate quantitative assessments of the structural heterogeneities of ccRCC slides obtained from human patients. Machine-learning-assisted segmentation of nuclei and cytoplasm enabled the quantification at the subcellular level. Compared to benign regions, malignant regions exhibited a considerable increase in structural heterogeneities. The results demonstrate that RI tomography provides quantitative information in synergy with stained images on the structural heterogeneities in ccRCC.
Files in This Item:
T202305457.pdf Download
DOI
10.1364/BOE.484092
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
Yonsei Authors
Shin, Su Jin(신수진) ORCID logo https://orcid.org/0000-0001-9114-8438
Lee, Kwang Suk(이광석) ORCID logo https://orcid.org/0000-0002-7961-8393
Heo, Ji Eun(허지은) ORCID logo https://orcid.org/0000-0002-4184-8468
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/196450
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