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Zwitterionic Inhaler with Synergistic Therapeutics for Reprogramming of M2 Macrophage to Pro-Inflammatory Phenotype

Authors
 Sungwon Jung  ;  Sungeun Heo  ;  Yoogyeong Oh  ;  Kyungtae Park  ;  Sohyeon Park  ;  Woojin Choi  ;  Yang-Hee Kim  ;  Se Yong Jung  ;  Jinkee Hong 
Citation
 ADVANCED HEALTHCARE MATERIALS, Vol.12(22) : e2300226, 2023-09 
Journal Title
ADVANCED HEALTHCARE MATERIALS
ISSN
 2192-2640 
Issue Date
2023-09
MeSH
Humans ; Lung ; Lung Diseases* ; Macrophages* ; Nebulizers and Vaporizers ; Phenotype
Keywords
anti-macrophage uptake ; anti-mucus ; drug delivery ; macrophage reprogramming ; synergistic therapeutics ; zwitterionic inhalers
Abstract
Myriad lung diseases are life threatening and macrophages play a key role in both physiological and pathological processes. Macrophages have each pro-/anti-inflammatory phenotype, and each lung disease can be aggravated by over-polarized macrophage. Therefore, development of a method capable of mediating the macrophage phenotype is one of the solutions for lung disease treatment. For mediating the phenotype of macrophages, the pulmonary delivery system (PDS) is widely used due to its advantages, such as high efficiency and accessibility of the lungs. However, it has a low drug delivery efficiency ironically because of the perfect lung defense system consisting of the mucus layer and airway macrophages. In this study, zwitterion-functionalized poly(lactide-co-glycolide) (PLGA) inhalable microparticles (ZwPG) are synthesized to increase the efficiency of the PDS. The thin layer of zwitterions formed on PLGA surface has high nebulizing stability and show high anti-mucus adhesion and evasion of macrophages. As a reprogramming agent for macrophages, ZwPG containing dexamethasone (Dex) and pirfenidone (Pir) are treated to over-polarized M2 macrophages. As a result, a synergistic effect of Dex/Pir induces reprogramming of M2 macrophage to pro-inflammatory phenotypes.
Full Text
https://onlinelibrary.wiley.com/doi/10.1002/adhm.202300226
DOI
10.1002/adhm.202300226
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Jung, Se Yong(정세용) ORCID logo https://orcid.org/0000-0003-1337-563X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/196435
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