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Sex differences in the relationship between platelet count and type 2 diabetes risk in community-dwelling adults: Longitudinal findings over 14 years
DC Field | Value | Language |
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dc.contributor.author | 이용제 | - |
dc.contributor.author | 서인호 | - |
dc.contributor.author | 이혜선 | - |
dc.contributor.author | 설소영 | - |
dc.date.accessioned | 2023-10-19T05:49:00Z | - |
dc.date.available | 2023-10-19T05:49:00Z | - |
dc.date.issued | 2023-09 | - |
dc.identifier.issn | 1520-7552 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/196284 | - |
dc.description.abstract | Aims: Emerging evidence suggests that platelet count predicts the development of type 2 diabetes; however, there is conflicting evidence concerning the relationship in men and women. This study aimed to assess the longitudinal association between platelet count and the incidence risk of type 2 diabetes. Materials and methods: Among 10,030 participants, 7325 participants (3439 men and 3886 women) without diabetes were selected from the Korean Genome and Epidemiology Study. Platelet count quartiles were divided as follows: Q1 ≤219, Q2, 220-254, Q3, 255-296 and Q4 ≥297 (x103 /ml) for men and ≤232, 233-266, 267-305 and ≥306 (x103 /μL) for women. The hazard ratios (HRs) with 95% confidential intervals (CIs) for incident type 2 diabetes were calculated using multiple Cox proportional hazards regression models according to sex-specific platelet count quartiles. Results: During the biennial follow-up period from 2001 to 2002 to 2013-2014, 750 male participants (21.8%, 750/3439) and 730 female participants (18.8%, 730/3886) had newly developed type 2 diabetes. For women, compared to the reference first quartile, the HRs for incident type 2 diabetes in the second, third, and fourth platelet count quartiles were 1.20 (0.96-1.50), 1.21(0.97-1.51), and 1.47 (1.18-1.82) after adjusting for age, body mass index, smoking status, alcohol intake, physical activity, mean arterial blood pressure, family history of diabetes, and HOMA-IR. However, these positive relationships were not observed in men after adjusting for the same co-variables. Conclusions: Platelet count was independently associated with an increased risk of incident type 2 diabetes only in women. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Wiley-Blackwell | - |
dc.relation.isPartOf | DIABETES-METABOLISM RESEARCH AND REVIEWS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Diabetes Mellitus, Type 2* / epidemiology | - |
dc.subject.MESH | Diabetes Mellitus, Type 2* / etiology | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Independent Living | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Platelet Count | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Sex Characteristics | - |
dc.subject.MESH | Smoking | - |
dc.title | Sex differences in the relationship between platelet count and type 2 diabetes risk in community-dwelling adults: Longitudinal findings over 14 years | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Family Medicine (가정의학교실) | - |
dc.contributor.googleauthor | Eun Kyeong Yun | - |
dc.contributor.googleauthor | In-Ho Seo | - |
dc.contributor.googleauthor | Hye Sun Lee | - |
dc.contributor.googleauthor | So-Young Seol | - |
dc.contributor.googleauthor | Yong-Jae Lee | - |
dc.identifier.doi | 10.1002/dmrr.3641 | - |
dc.contributor.localId | A02982 | - |
dc.relation.journalcode | J00725 | - |
dc.identifier.eissn | 1520-7560 | - |
dc.identifier.pmid | 37009687 | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/10.1002/dmrr.3641 | - |
dc.subject.keyword | platelet count | - |
dc.subject.keyword | prospective cohort study | - |
dc.subject.keyword | type 2 diabetes | - |
dc.contributor.alternativeName | Lee, Yong Jae | - |
dc.contributor.affiliatedAuthor | 이용제 | - |
dc.citation.volume | 39 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | e3641 | - |
dc.identifier.bibliographicCitation | DIABETES-METABOLISM RESEARCH AND REVIEWS, Vol.39(6) : e3641, 2023-09 | - |
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