0 208

Cited 0 times in

Sex differences in the relationship between platelet count and type 2 diabetes risk in community-dwelling adults: Longitudinal findings over 14 years

DC Field Value Language
dc.contributor.author이용제-
dc.contributor.author서인호-
dc.contributor.author이혜선-
dc.contributor.author설소영-
dc.date.accessioned2023-10-19T05:49:00Z-
dc.date.available2023-10-19T05:49:00Z-
dc.date.issued2023-09-
dc.identifier.issn1520-7552-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/196284-
dc.description.abstractAims: Emerging evidence suggests that platelet count predicts the development of type 2 diabetes; however, there is conflicting evidence concerning the relationship in men and women. This study aimed to assess the longitudinal association between platelet count and the incidence risk of type 2 diabetes. Materials and methods: Among 10,030 participants, 7325 participants (3439 men and 3886 women) without diabetes were selected from the Korean Genome and Epidemiology Study. Platelet count quartiles were divided as follows: Q1 ≤219, Q2, 220-254, Q3, 255-296 and Q4 ≥297 (x103 /ml) for men and ≤232, 233-266, 267-305 and ≥306 (x103 /μL) for women. The hazard ratios (HRs) with 95% confidential intervals (CIs) for incident type 2 diabetes were calculated using multiple Cox proportional hazards regression models according to sex-specific platelet count quartiles. Results: During the biennial follow-up period from 2001 to 2002 to 2013-2014, 750 male participants (21.8%, 750/3439) and 730 female participants (18.8%, 730/3886) had newly developed type 2 diabetes. For women, compared to the reference first quartile, the HRs for incident type 2 diabetes in the second, third, and fourth platelet count quartiles were 1.20 (0.96-1.50), 1.21(0.97-1.51), and 1.47 (1.18-1.82) after adjusting for age, body mass index, smoking status, alcohol intake, physical activity, mean arterial blood pressure, family history of diabetes, and HOMA-IR. However, these positive relationships were not observed in men after adjusting for the same co-variables. Conclusions: Platelet count was independently associated with an increased risk of incident type 2 diabetes only in women.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherWiley-Blackwell-
dc.relation.isPartOfDIABETES-METABOLISM RESEARCH AND REVIEWS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAdult-
dc.subject.MESHDiabetes Mellitus, Type 2* / epidemiology-
dc.subject.MESHDiabetes Mellitus, Type 2* / etiology-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHIndependent Living-
dc.subject.MESHMale-
dc.subject.MESHPlatelet Count-
dc.subject.MESHRisk Factors-
dc.subject.MESHSex Characteristics-
dc.subject.MESHSmoking-
dc.titleSex differences in the relationship between platelet count and type 2 diabetes risk in community-dwelling adults: Longitudinal findings over 14 years-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Family Medicine (가정의학교실)-
dc.contributor.googleauthorEun Kyeong Yun-
dc.contributor.googleauthorIn-Ho Seo-
dc.contributor.googleauthorHye Sun Lee-
dc.contributor.googleauthorSo-Young Seol-
dc.contributor.googleauthorYong-Jae Lee-
dc.identifier.doi10.1002/dmrr.3641-
dc.contributor.localIdA02982-
dc.relation.journalcodeJ00725-
dc.identifier.eissn1520-7560-
dc.identifier.pmid37009687-
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/10.1002/dmrr.3641-
dc.subject.keywordplatelet count-
dc.subject.keywordprospective cohort study-
dc.subject.keywordtype 2 diabetes-
dc.contributor.alternativeNameLee, Yong Jae-
dc.contributor.affiliatedAuthor이용제-
dc.citation.volume39-
dc.citation.number6-
dc.citation.startPagee3641-
dc.identifier.bibliographicCitationDIABETES-METABOLISM RESEARCH AND REVIEWS, Vol.39(6) : e3641, 2023-09-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.