0 100

Cited 4 times in

Clinical and histologic factors associated with discordance between steatosis grade derived from histology vs. MRI-PDFF in NAFLD

Authors
 Beom K Kim  ;  Nicole Bernstein  ;  Daniel Q Huang  ;  Nobuharu Tamaki  ;  Kento Imajo  ;  Masato Yoneda  ;  Nancy Sutter  ;  Jinho Jung  ;  Khang Nguyen  ;  Leyna Nguyen  ;  Tracy Le  ;  Egbert Madamba  ;  Lisa Richards  ;  Mark A Valasek  ;  Cynthia Behling  ;  Claude B Sirlin  ;  Atsushi Nakajima  ;  Rohit Loomba 
Citation
 ALIMENTARY PHARMACOLOGY & THERAPEUTICS, Vol.58(2) : 229-237, 2023-07 
Journal Title
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
ISSN
 0269-2813 
Issue Date
2023-07
MeSH
Fibrosis ; Humans ; Liver / diagnostic imaging ; Liver / pathology ; Magnetic Resonance Imaging ; Non-alcoholic Fatty Liver Disease* / diagnostic imaging ; Non-alcoholic Fatty Liver Disease* / pathology ; Protons
Keywords
NAFLD ; discordance ; liver biopsy ; magnetic resonance imaging ; proton density fat fraction
Abstract
Background: Magnetic resonance imaging-proton density fat fraction (MRI-PDFF) is an excellent biomarker for the non-invasive quantification of hepatic steatosis.

Aim: To examine clinical and histologic factors associated with discordance between steatosis grade determined by histology and MRI-PDFF in patients with non-alcoholic fatty liver disease (NAFLD) METHODS: We included 728 patients with biopsy-proven NAFLD from UC San Diego (n = 414) and Yokohama City University (n = 314) who underwent MRI-PDFF and liver biopsy. Patients were stratified by steatosis, and matched with MRI-PDFF cut-points for each steatosis grade: 0 (MRI-PDFF < 6.4%), 1 (MRI-PDFF: 6.4%-17.4%), 2 (MRI-PDFF: 17.4%-22.1%), 3 (MRI-PDFF ≥ 22.1%). Primary outcome was major discordance defined as ≥2 steatosis grade difference determined by histology and MRI-PDFF.

Results: Mean (±SD) age and BMI were 55.3 (±13.8) years and 29.9 (±4.9) kg/m2 , respectively. The distributions of histology and MRI-PDFF-determined steatosis were 5.5% grade 0 (n = 40), 44.8% 1 (n = 326, 44.8%), 33.9% 2 (n = 247), and 15.8% 3 (n = 115) vs. 23.5% grade 0 (n = 171), 49.7% 1 (n = 362), 12.9% 2 (n = 94), and 13.9% 3 (n = 101). Major discordance rate was 6.6% (n = 48). Most cases with major discordance had greater histology-determined steatosis grade (n = 40, 88.3%), higher serum AST and liver stiffness, and greater likelihood of fibrosis ≥2, ballooning ≥1 and lobular inflammation ≥2 (all p < 0.05).

Conclusion: Histology overestimates steatosis grade compared to MRI-PDFF. Patients with advanced NASH are likely to be upgraded on steatosis grade by histology. These data have important implications for steatosis estimation and reporting on histology in clinical practice and trials, especially in patients with stage 2 fibrosis.
Full Text
https://onlinelibrary.wiley.com/doi/full/10.1111/apt.17564
DOI
10.1111/apt.17564
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Beom Kyung(김범경) ORCID logo https://orcid.org/0000-0002-5363-2496
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/196257
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links