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카바페넴 분해효소 생성 장내세균목의 검사실학적 진단법

Other Titles
 Laboratory Diagnosis of Carbapenemase-producing Enterobacterales 
Authors
 김남희  ;  홍기호  ;  박정수  ;  노경호  ;  신수 
Citation
 Korean Journal of Healthcare-associated Infection Control and Prevention (의료관련감염관리), Vol.28(1) : 42-49, 2023-06 
Journal Title
Korean Journal of Healthcare-associated Infection Control and Prevention(의료관련감염관리)
Issue Date
2023-06
Keywords
Carbapenem-resistant Enterobacterales ; Carbapenemase-producing Enterobacterales ; Laboratory diagnosis ; Phenotypic test ; Molecular test
Abstract
Carbapenem-resistant enterobacterales (CREs) are pathogens of special concern in healthcareassociated infections. Enterobacterales become resistant to carbapenems through several mechanisms, including carbapenemase enzyme production. Enterobacterales that produce carbapenemase are known as carbapenemase-producing enterobacterales (CPEs). Genes encoding carbapenemase are usually found on plasmids that can transmit horizontally between strains, which could explain the rapid spread of carbapenem resistance. Timely and accurate laboratory tests of CPE are necessary to prevent and treat these infections. Various phenotypic tests, such as the modified Hodge test, modified carbapenem inactivation method (mCIM) with or without EDTA-CIM (eCIM), chromogenic agar test, carba NP, immunoassay, mass spectrometry, and molecular tests are available. In this study, we discussed the importance of CRE and CPE control in the COVID-19 pandemic era and summarized several laboratory CPE detection methods currently utilized in clinical microbiology laboratories.
Files in This Item:
T202304529.pdf Download
DOI
10.14192/kjicp.2023.28.1.42
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Hong, Ki Ho(홍기호) ORCID logo https://orcid.org/0000-0002-5700-9036
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/196159
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