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Association of non-high-density lipoprotein cholesterol trajectories with the development of non-alcoholic fatty liver disease: an epidemiological and genome-wide association study
DC Field | Value | Language |
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dc.contributor.author | 권유진 | - |
dc.date.accessioned | 2023-08-09T06:51:51Z | - |
dc.date.available | 2023-08-09T06:51:51Z | - |
dc.date.issued | 2023-07 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/195986 | - |
dc.description.abstract | Background: Non-alcoholic fatty liver disease (NAFLD) shares common risk factors with cardiovascular diseases. Effects of longitudinal trends in non-high-density lipoprotein (non-HDL) cholesterol on NAFLD development are not understood. This study aimed to assess the relationship between non-HDL cholesterol trajectories and the incidence of NAFLD and to identify genetic differences contributing to NAFLD development between non-HDL cholesterol trajectory groups. Methods: We analyzed data from 2203 adults (aged 40-69 years) who participated in the Korean Genome and Epidemiology Study. During the 6-year exposure periods, participants were classified into an increasing non-HDL cholesterol trajectory group (n = 934) or a stable group (n = 1269). NAFLD was defined using a NAFLD-liver fat score > -0.640. Multiple Cox proportional hazard regression analysis estimated the hazard ratio (HR) and the 95% confidence interval (CI) for the incidence of NAFLD in the increasing group compared with the stable group. Results: A genome-wide association study identified significant single-nucleotide polymorphisms (SNPs) associated with NAFLD. During the median 7.8-year of event accrual period, 666 (30.2%) newly developed NAFLD cases were collected. Compared with the stable non-HDL group, the adjusted HR (95% CI) for the incidence of NAFLD in the increasing non-HDL cholesterol group was 1.46 (1.25-1.71). Although there were no significant SNPs, the polygenic risk score was highest in the increasing group, followed by the stable and control groups. Conclusion: Our study indicates that lifestyle or environmental factors have a greater effect size than genetic factors in NAFLD progression risk. Lifestyle modification could be an effective prevention strategy for NAFLD for people with elevated non-HDL cholesterol. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | BioMed Central | - |
dc.relation.isPartOf | JOURNAL OF TRANSLATIONAL MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Cholesterol | - |
dc.subject.MESH | Genome-Wide Association Study | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Lipoproteins | - |
dc.subject.MESH | Non-alcoholic Fatty Liver Disease* / complications | - |
dc.subject.MESH | Non-alcoholic Fatty Liver Disease* / epidemiology | - |
dc.subject.MESH | Non-alcoholic Fatty Liver Disease* / genetics | - |
dc.subject.MESH | Risk Factors | - |
dc.title | Association of non-high-density lipoprotein cholesterol trajectories with the development of non-alcoholic fatty liver disease: an epidemiological and genome-wide association study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Family Medicine (가정의학교실) | - |
dc.contributor.googleauthor | Jun-Hyuk Lee | - |
dc.contributor.googleauthor | Jiyeon Kim | - |
dc.contributor.googleauthor | Jung Oh Kim | - |
dc.contributor.googleauthor | Yu-Jin Kwon | - |
dc.identifier.doi | 10.1186/s12967-023-04291-4 | - |
dc.contributor.localId | A04882 | - |
dc.relation.journalcode | J01915 | - |
dc.identifier.eissn | 1479-5876 | - |
dc.identifier.pmid | 37403158 | - |
dc.subject.keyword | Generic risk score | - |
dc.subject.keyword | Genome-wide association studies | - |
dc.subject.keyword | Non-alcoholic fatty liver disease | - |
dc.subject.keyword | Non-high-density lipoprotein cholesterol | - |
dc.subject.keyword | Trajectory model | - |
dc.contributor.alternativeName | Kwon, Yu-Jin | - |
dc.contributor.affiliatedAuthor | 권유진 | - |
dc.citation.volume | 21 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 435 | - |
dc.identifier.bibliographicCitation | JOURNAL OF TRANSLATIONAL MEDICINE, Vol.21(1) : 435, 2023-07 | - |
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