Cited 5 times in
Transcriptional and Epigenetic Regulation of Context-Dependent Plasticity in T-Helper Lineages
DC Field | Value | Language |
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dc.contributor.author | 이준용 | - |
dc.date.accessioned | 2023-08-09T06:40:05Z | - |
dc.date.available | 2023-08-09T06:40:05Z | - |
dc.date.issued | 2023-02 | - |
dc.identifier.issn | 1598-2629 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/195923 | - |
dc.description.abstract | Thcell lineage determination and functional specialization are tightly linked to the activation of lineage-determining transcription factors (TFs) that bind cis-regulatory elements. These lineage-determining TFs act in concert with multiple layers of transcriptional regulators to alter the epigenetic landscape, including DNA methylation, histone modification and three-dimensional chromosome architecture, in order to facilitate the specific Th gene expression programs that allow for phenotypic diversification. Accumulating evidence indicates that Th cell differentiation is not as rigid as classically held; rather, extensive phenotypic plasticity is an inherent feature of T cell lineages. Recent studies have begun to uncover the epigenetic programs that mechanistically govern T cell subset specification and immunological memory. Advances in next generation sequencing technologies have allowed global transcriptomic and epigenomic interrogation of CD4+ Th cells that extends previous findings focusing on individual loci. In this review, we provide an overview of recent genome-wide insights into the transcriptional and epigenetic regulation of CD4+ T cell-mediated adaptive immunity and discuss the implications for disease as well as immunotherapies. © 2023, Korean Association of Immunologists. All rights reserved. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Korea Society for Immunology : Korean Society of Biological Response Modifiers | - |
dc.relation.isPartOf | IMMUNE NETWORK | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Transcriptional and Epigenetic Regulation of Context-Dependent Plasticity in T-Helper Lineages | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Microbiology (미생물학교실) | - |
dc.contributor.googleauthor | Meyer J Friedman | - |
dc.contributor.googleauthor | Haram Lee | - |
dc.contributor.googleauthor | June-Yong Lee | - |
dc.contributor.googleauthor | Soohwan Oh | - |
dc.identifier.doi | 10.4110/in.2023.23.e5 | - |
dc.contributor.localId | A06330 | - |
dc.relation.journalcode | J01033 | - |
dc.identifier.eissn | 2092-6685 | - |
dc.identifier.pmid | 36911799 | - |
dc.subject.keyword | Cancer | - |
dc.subject.keyword | Cell plasticity | - |
dc.subject.keyword | Cellular microenvironment | - |
dc.subject.keyword | Epigenomics | - |
dc.subject.keyword | Helper T-lymphocytes | - |
dc.subject.keyword | Inflammation | - |
dc.contributor.alternativeName | Lee, June-Yong | - |
dc.contributor.affiliatedAuthor | 이준용 | - |
dc.citation.volume | 23 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | e5 | - |
dc.identifier.bibliographicCitation | IMMUNE NETWORK, Vol.23(1) : e5, 2023-02 | - |
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