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Health-related quality of life of children with pre-dialysis chronic kidney disease

 Hee Sun Baek  ;  Hee Gyung Kang  ;  Hyun Jin Choi  ;  Hae Il Cheong  ;  Il Soo Ha  ;  Kyung Hee Han  ;  Seong Heon Kim  ;  Hee Yeon Cho  ;  Jae Il Shin  ;  Young Seo Park  ;  Joo Hoon Lee  ;  Joongyub Lee  ;  Curie Ahn  ;  Min Hyun Cho 
 PEDIATRIC NEPHROLOGY, Vol.32(11) : 2097-2105, 2017-11 
Journal Title
Issue Date
Adolescent ; Asian People / psychology ; Child ; Child, Preschool ; Cross-Sectional Studies ; Female ; Humans ; Infant ; Male ; Parents / psychology ; Quality of Life / psychology* ; Renal Dialysis / psychology* ; Renal Insufficiency, Chronic / psychology* ; Renal Insufficiency, Chronic / therapy ; Republic of Korea ; Self Report ; Surveys and Questionnaires
Children ; Chronic kidney disease ; Cohort ; Quality of life
Background: The goal of this study was to evaluate the quality of life (QOL) of Asian children with pre-dialysis chronic kidney disease (CKD) and to reveal the factors influencing the QOL of children with CKD.

Methods: We performed a cross-sectional study of the PedsQL 4.0 Generic Core Scale Module in the KNOW-PedCKD (KoreaN cohort study for Outcome in patients with Pediatric Chronic Kidney Disease) cohort, and compared the child self-reported and parent proxy-reported QOL of the pediatric cohort. From 2011 through 2016, a total of 376 children with CKD were enrolled after informed consent was obtained from parents or caregivers in seven pediatric nephrology centers.

Results: In parent proxy-reports, male patients had a better QOL than female patients in the Physical Functioning category. In child self-reports, male patients had better QOL than female patients in the Physical, Emotional, and School Functioning categories. According to CKD stage, there were significant differences in the QOL score in all categories of parent proxy-reports, and patients with higher CKD stage (lower glomerular filtration rate) had a worse QOL. Growth parameters showed a significantly positive correlation with the QOL score in all categories.

Conclusions: The QOL of children with predialysis CKD is affected by various factors, including sex, glomerular filtration rate (GFR), socio-economic status, existence of co-morbidities, anemia, growth retardation, and behavioral disorders. To improve their QOL, it is important to objectively understand the respective effects of these factors and attempt early intervention.
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1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Shin, Jae Il(신재일) ORCID logo https://orcid.org/0000-0003-2326-1820
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