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Prognostic group stratification and nomogram for predicting overall survival in patients who received radiotherapy for abdominal lymph node metastasis from hepatocellular carcinoma: a multi-institutional retrospective study (KROG 15-02)

 Youngkyong Kim  ;  Hee Chul Park  ;  Sang Min Yoon  ;  Tae Hyun Kim  ;  Jieun Lee  ;  Jinhyun Choi  ;  Jeong Il Yu  ;  Jin-Hong Park  ;  Jong Hoon Kim  ;  Joong-Won Park  ;  Jinsil Seong 
 ONCOTARGET, Vol.8(55) : 94450-94461, 2017-10 
Journal Title
Issue Date
hepatocellular carcinoma ; lymph node metastasis ; nomogram ; prognostic factor ; survival
Objective: To develop a prognostic model for overall survival (OS) in hepatocellular carcinoma (HCC) patients receiving radiotherapy (RT) to metastatic abdominal lymph nodes (LNs).

Materials and methods: Two hundred twenty-eight patients treated with RT to metastatic abdominal LNs were retrospectively reviewed.

Results: Median OS in all patients was 11.1 months. LN responders had significantly higher median OS than non-responders (14.2 months vs. 7.5 months, p<0.05). On multivariate analysis, Child-Pugh classification, status of intrahepatic tumor, presence of distant metastasis, number and location of metastatic LNs, serum level of alpha fetoprotein (AFP), and the LN response to RT were significant prognostic factors for OS (p < 0.05 each). Based on the results of multivariate analysis, prognostic group stratification according to the number of pre-treatment risk factors was a significant predictor of OS, and median OS in patients with ≥ 4, 3, 2, 1, and 0 risk factors were 2.9, 5.5, 10.3, 13.6, and 27.8 months, respectively (p<0.05). A nomogram was formulated by integrating the different prognostic contribution of each factor, and it showed good accuracy for predicting 2-year OS with a concordance index of 0.72.

Conclusion: Prognostic group stratification and nomogram could be useful prognostic and therapeutic indicators in selecting treatment strategies.
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1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
Yonsei Authors
Seong, Jin Sil(성진실) ORCID logo https://orcid.org/0000-0003-1794-5951
Choi, Jinhyun(최진현)
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