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Optimal radiation dose for patients with one to three lymph node positive breast cancer following breast-conserving surgery and anthracycline plus taxane-based chemotherapy: A retrospective multicenter analysis (KROG 1418)

Authors
 Haeyoung Kim  ;  Won Park  ;  Jeong Il Yu  ;  Doo Ho Choi  ;  Seung Jae Huh  ;  Yeon-Joo Kim  ;  Eun Sook Lee  ;  Keun Seok Lee  ;  Han-Sung Kang  ;  In Hae Park  ;  Kyung Hwan Shin  ;  Kyubo Kim  ;  Kyung Ran Park  ;  Yong Bae Kim  ;  Sung Ja Ahn  ;  Jong Hoon Lee  ;  Jin Hee Kim  ;  Mison Chun  ;  Hyung-Sik Lee  ;  Jung Soo Kim  ;  Jong-Young Lee 
Citation
 ONCOTARGET, Vol.8(1) : 1796-1804, 2017-01 
Journal Title
ONCOTARGET
Issue Date
2017-01
MeSH
Adult ; Aged ; Anthracyclines / therapeutic use ; Antineoplastic Agents / therapeutic use ; Antineoplastic Combined Chemotherapy Protocols / therapeutic use ; Breast Neoplasms / mortality ; Breast Neoplasms / pathology* ; Breast Neoplasms / radiotherapy* ; Bridged-Ring Compounds / therapeutic use ; Disease-Free Survival ; Dose-Response Relationship, Radiation* ; Female ; Humans ; Lymph Node Excision ; Lymph Nodes / pathology ; Lymphatic Metastasis / pathology ; Mastectomy, Segmental ; Middle Aged ; Radiation Dosage* ; Retrospective Studies ; Taxoids / therapeutic use ; Young Adult
Keywords
breast neoplasms ; dose-response relationship ; prognosis ; radiotherapy
Abstract
Background and purpose: This study was performed to determine optimal radiation dose in pN1 breast cancer patients who received breast conserving surgery (BCS) and anthracycline plus taxane (AT)-based chemotherapy.

Materials and methods: Retrospective chart reviews were performed in 1,147 patients who were treated between January 2006 and December 2010. The impact of radiation dose on treatment outcomes was evaluated.

Results: Median follow-up time was 66 months. The 5-year rate of disease-free survival (DFS) was 93.2%. Larger tumor size (> 20 mm), positive lymphovascular invasion, high histologic grade, and high ratio of positive nodes (> 0.1) were significantly associated with inferior DFS. By using the 4 factors related to DFS, patients were categorized into high-risk (with ≥ 3 factors) and low-risk (with < 3 factors) groups. In the high-risk group, higher radiation dose (> 60.3 GyEQD2) was significantly associated with better DFS than the lower dose (≤ 60.3 GyEQD2). However, the radiation dose did not impact DFS in the low-risk group.

Conclusions: Dosing of radiation affects the outcome of post-BCS radiotherapy in pN1 breast cancer. Doses of over 60.3 GyEQD2 were associated with better outcome in the high-risk patients.
Files in This Item:
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DOI
10.18632/oncotarget.12882
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
Yonsei Authors
Kim, Yong Bae(김용배) ORCID logo https://orcid.org/0000-0001-7573-6862
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/195848
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