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Safety and Efficacy of Gevokizumab in Patients with Behçet's Disease Uveitis: Results of an Exploratory Phase 2 Study
DC Field | Value | Language |
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dc.contributor.author | 이성철 | - |
dc.date.accessioned | 2023-08-09T02:47:51Z | - |
dc.date.available | 2023-08-09T02:47:51Z | - |
dc.date.issued | 2017-02 | - |
dc.identifier.issn | 0927-3948 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/195844 | - |
dc.description.abstract | Purpose: To evaluate the safety and efficacy of gevokizumab for the treatment of Behçet's disease uveitis in a prospective, open-label, randomized phase 2 trial. Methods: Behçet's disease patients with new acute ocular exacerbation or at risk of exacerbation received 30 or 60 mg gevokizumab every 4 weeks intravenously or subcutaneously, on top of a stable regimen of immunosuppressives and corticosteroids (≤20 mg/day equivalent prednisolone). Patients withdrew in cases of ocular exacerbation. Results: A total of 21 patients were included (17 acute and 4 at-risk; mean duration of uveitis 45.6 ± 37.4 months). There were no serious adverse events related to gevokizumab. Recorded adverse events were mostly associated with exacerbation of uveitis or its complications. Response was evaluated for 14 acute patients and all showed rapid control of acute ocular exacerbation, mostly within 1 week, without any increase in corticosteroid dosage. Conclusions: Gevokizumab was well tolerated and rapidly controlled acute ocular exacerbations of Behçet's disease uveitis without the need for high-dose corticosteroid. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Informa Healthcare | - |
dc.relation.isPartOf | OCULAR IMMUNOLOGY AND INFLAMMATION | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Antibodies, Monoclonal, Humanized / adverse effects | - |
dc.subject.MESH | Antibodies, Monoclonal, Humanized / therapeutic use* | - |
dc.subject.MESH | Behcet Syndrome / drug therapy* | - |
dc.subject.MESH | Behcet Syndrome / physiopathology | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Glucocorticoids / administration & dosage | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunosuppressive Agents / adverse effects | - |
dc.subject.MESH | Immunosuppressive Agents / therapeutic use* | - |
dc.subject.MESH | Injections, Intravenous | - |
dc.subject.MESH | Injections, Subcutaneous | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | Treatment Outcome | - |
dc.subject.MESH | Uveitis / drug therapy* | - |
dc.subject.MESH | Uveitis / physiopathology | - |
dc.subject.MESH | Visual Acuity | - |
dc.title | Safety and Efficacy of Gevokizumab in Patients with Behçet's Disease Uveitis: Results of an Exploratory Phase 2 Study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Ophthalmology (안과학교실) | - |
dc.contributor.googleauthor | Ilknur Tugal-Tutkun | - |
dc.contributor.googleauthor | Sibel Kadayifcilar | - |
dc.contributor.googleauthor | Moncef Khairallah | - |
dc.contributor.googleauthor | Sung Chul Lee | - |
dc.contributor.googleauthor | Pinar Ozdal | - |
dc.contributor.googleauthor | Yilmaz Özyazgan | - |
dc.contributor.googleauthor | Ji Hun Song | - |
dc.contributor.googleauthor | Hyeong Gon Yu | - |
dc.contributor.googleauthor | Valerie Lehner | - |
dc.contributor.googleauthor | Agnès de Cordoue | - |
dc.contributor.googleauthor | Oana Bernard | - |
dc.contributor.googleauthor | Ahmet Gül | - |
dc.identifier.doi | 10.3109/09273948.2015.1092558 | - |
dc.contributor.localId | A02873 | - |
dc.relation.journalcode | J03485 | - |
dc.identifier.eissn | 1744-5078 | - |
dc.identifier.pmid | 26829647 | - |
dc.identifier.url | https://www.tandfonline.com/doi/full/10.3109/09273948.2015.1092558 | - |
dc.subject.keyword | Behçet’s disease | - |
dc.subject.keyword | gevokizumab | - |
dc.subject.keyword | interleukin-1 beta | - |
dc.subject.keyword | retinal vasculitis | - |
dc.subject.keyword | uveitis | - |
dc.contributor.alternativeName | Lee, Sung Chul | - |
dc.contributor.affiliatedAuthor | 이성철 | - |
dc.citation.volume | 25 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 62 | - |
dc.citation.endPage | 70 | - |
dc.identifier.bibliographicCitation | OCULAR IMMUNOLOGY AND INFLAMMATION, Vol.25(1) : 62-70, 2017-02 | - |
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