0 43

Cited 0 times in

Treatment Patterns and Patient Reported Outcomes in Benign Prostatic Hyperplasia Patients with Overactive Bladder Symptoms

 Yong Hyun Park  ;  Tae Hyo Kim  ;  Seung Wook Lee  ;  Byung Ha Chung  ;  Jin Seon Cho  ;  Ji Youl Lee 
 LUTS-LOWER URINARY TRACT SYMPTOMS, Vol.9(2) : 75-81, 2017-05 
Journal Title
Issue Date
Adrenergic alpha-Antagonists / therapeutic use* ; Analysis of Variance ; Cholinergic Antagonists / therapeutic use* ; Drug Therapy, Combination ; Humans ; Male ; Middle Aged ; Nocturia / drug therapy ; Nocturia / physiopathology ; Patient Reported Outcome Measures ; Prospective Studies ; Prostatic Hyperplasia / drug therapy* ; Prostatic Hyperplasia / physiopathology ; Surveys and Questionnaires ; Treatment Outcome ; Urinary Bladder, Overactive / drug therapy* ; Urinary Bladder, Overactive / physiopathology ; Urination / physiology
benign prostatic hyperplasia ; clinical outcomes ; overactive bladder symptoms ; patient-reported outcomes ; treatment pattern
Objectives: We aimed to examine the treatment patterns, and patient-reported outcomes (PROs) in benign prostatic hyperplasia (BPH) patients with overactive bladder (OAB) symptoms.

Methods: Seven hundred and forty seven patients were included in this prospective observational study. The primary endpoint was to describe the medical treatment patterns for BPH patients with OAB symptoms. The secondary endpoint was to determine the PROs of these patients. Clinical outcome was assessed using International prostate symptom score (IPSS), and PROs were measured using BPH-Related QoL Questionnaire Korea 1 (BPH QoL K1) and Euroqol-5 Dimension (EQ-5D).

Results: When starting the study, 391 patients (52.3%) received α-blocker monotherapy, whereas 356 (47.7%) received combination therapy with anticholinergics. Of the 369 patients who completed the 6-month treatment, 139 patients (37.7%) still received α-blocker monotherapy, 122 (33.1%) still received combination therapy with anticholinergics, and 108 (29.3%) received subsequent anticholinergics in addition to α-blocker. When the patients were stratified, storage subscore was higher (9.5 vs. 8.8, P = 0.034) and voiding subscore (9.7 vs. 11.6, P = 0.001) was lower in patients with anticholinergics than those without it. Although all treatment groups reported a significant improvement from baseline, no significant between-group differences in changes in IPSS, EQ-5D and BPH QoL K1 was found.

Conclusions: About one-third of patients received α-blocker monotherapy, one-third received combination therapy with anticholinergics, and another one-third received subsequent anticholinergics in addition to α-blocker. Storage subscore was higher in patients with anticholinergics than those without it, but vice-versa for voiding subscore. Similar improvement on clinical outcomes and PROs was observed in all treatment groups.
Full Text
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
Yonsei Authors
Chung, Byung Ha(정병하) ORCID logo https://orcid.org/0000-0001-9817-3660
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.