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Significance of Serology by Multi-Antigen ELISA for Tissue Helminthiases in Korea

Authors
 Yan Jin  ;  Eun Min Kim  ;  Min Ho Choi  ;  Myoung Don Oh  ;  Sung Tae Hong 
Citation
 JOURNAL OF KOREAN MEDICAL SCIENCE, Vol.32(7) : 1118-1123, 2017-07 
Journal Title
JOURNAL OF KOREAN MEDICAL SCIENCE
ISSN
 1011-8934 
Issue Date
2017-07
MeSH
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Antibodies, Helminth / blood* ; Antigens, Helminth / immunology ; Child ; Child, Preschool ; Clonorchiasis / blood ; Clonorchiasis / diagnosis ; Clonorchiasis / epidemiology* ; Clonorchiasis / parasitology ; Cross Reactions / immunology ; Cysticercosis / blood ; Cysticercosis / diagnosis ; Cysticercosis / epidemiology* ; Cysticercosis / parasitology ; Enzyme-Linked Immunosorbent Assay ; Female ; Humans ; Immunoglobulin G / blood ; Infant ; Male ; Middle Aged ; Paragonimiasis / blood ; Paragonimiasis / diagnosis ; Paragonimiasis / epidemiology* ; Paragonimiasis / parasitology ; Republic of Korea ; Seroepidemiologic Studies ; Serologic Tests ; Sparganosis / blood ; Sparganosis / diagnosis ; Sparganosis / epidemiology* ; Sparganosis / parasitology ; Young Adult
Keywords
Cross-Reaction ; ELISA ; IgG Antibody ; Korea ; Multiple Infections ; Seropositivity ; Tissue Helminthiases
Abstract
It is clinically important to differentiate tissue-invading helminthiasis. The purpose of this study was to assess the specific immunoglobulin G (IgG) antibody positive rates for clonorchiasis, paragonimiasis, cysticercosis, and sparganosis 4 helminthiases from 1996 to 2006 using multi-antigen enzyme-linked immunosorbent assay (ELISA) in Korea. Results of 6,017 samples, which were referred to our institute for serodiagnosis, were analyzed. The subjects with positive serum IgG antibodies were 1,502 (25.0%) for any of the 4 helminthiases. The overall positive numbers for clonorchiasis, paragonimiasis, cysticercosis, and sparganosis were 728 (12.1%), 166 (2.8%), 729 (12.1%), and 263 (4.4%), respectively. The positive serologic reaction to multi-antigens was determined in 309 (20.6%) of the 1,502 total seropositive subjects. Those with multi-antigen positivity were regarded as positive for the antigen of strongest reaction but cross-reaction to others with weak positive reaction. Annual seropositive rates for those 4 tissue helminthiases ranged from 12.1% to 35.7%. The highest rate was observed in age from 60 to 69 years old and prevalence of men (27.4%; 1,030/3,763) was significantly higher than of women (19.1%; 332/1,741). Hospital records of 165 ELISA positive patients were reviewed to confirm correlation with their clinical diagnosis. Paragonimiasis was highly correlated as 81.8% (9/11), cysticercosis 29.9% (20/67), clonorchiasis 29.0% (20/69), and sparganosis 11.1% (2/18). In conclusion, the multi-antigen ELISA using 4 helminth antigens is useful to differentiate suspected tissue-invading helminthiases, especially ELISA diagnosis of paragonimiasis is reliable. The seropositivity is still high among suspected patients in Korea.
Files in This Item:
T992017123.pdf Download
DOI
10.3346/jkms.2017.32.7.1118
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Tropica Medicine (열대의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Eun Min(김은민)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/195779
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