Efficacy and Safety of Atomoxetine Hydrochloride in Asian Adults With ADHD
Authors
Taro Goto ; Yuko Hirata ; Yasushi Takita ; Paula T Trzepacz ; Albert J Allen ; Dong-Ho Song ; Susan Shur-Fen Gau ; Hironobu Ichikawa ; Michihiro Takahashi
Citation
JOURNAL OF ATTENTION DISORDERS, Vol.21(2) : 100-109, 2017-01
Adrenergic Uptake Inhibitors / administration & dosage* ; Adrenergic Uptake Inhibitors / adverse effects ; Adult ; Asian People / ethnology ; Atomoxetine Hydrochloride / administration & dosage* ; Atomoxetine Hydrochloride / adverse effects ; Attention Deficit Disorder with Hyperactivity / drug therapy* ; Attention Deficit Disorder with Hyperactivity / ethnology ; Double-Blind Method ; Drug Administration Schedule ; Drug Substitution ; Executive Function / drug effects ; Female ; Humans ; Japan / ethnology ; Male ; Quality of Life ; Republic of Korea ; Taiwan ; Treatment Outcome
Keywords
Asian population ; adult ADHD ; atomoxetine ; executive function ; quality of life
Abstract
Objective: The efficacy and safety of atomoxetine was assessed in adult ADHD patients from Japan, Korea, and Taiwan in this first placebo-controlled Asian clinical study in adults of an ADHD medication.
Method: Atomoxetine was compared with placebo (195 atomoxetine, 196 placebo) over 10 weeks. The change from baseline to endpoint and changes over time in the Conners' Adult ADHD Rating Scale-Investigator Rated: Screening Version total score (CAARS-Inv: SV total score) were assessed along with changes in quality of life (QoL) and executive function.
Results: Atomoxetine treatment resulted in a mean reduction of -14.3 (placebo, -8.8) in CAARS-Inv: SV total score and a steady increase of between-group differences from Week 2. Improvements in QoL and executive functioning were also observed. Treatment-emergent adverse events leading to discontinuation were infrequent (atomoxetine: 5.2%, placebo: 1.5%).
Conclusion: Atomoxetine was tolerable and effective in improving QoL and executive function as well as ameliorating core ADHD symptoms in adult Asian patients.