Cited 8 times in
Gender-dimorphic effects of adipose-derived stromal vascular fractions on HUVECs exposed to oxidative stress
DC Field | Value | Language |
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dc.date.accessioned | 2023-08-09T02:39:39Z | - |
dc.date.available | 2023-08-09T02:39:39Z | - |
dc.date.issued | 2017-07 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/195722 | - |
dc.description.abstract | Stromal vascular fractions (SVFs) are a heterogeneous collection of cells within adipose tissue that are being studied for various clinical indications. In this study, we aimed to determine whether SVF transplantation into impaired tissues has differential effects on inflammatory and angiogenetic properties with regard to gender. As reactive oxygen species have been implicated in cardiovascular disease development, we investigated differences in gene and protein expression related to inflammation and angiogenesis in HUVECs co-cultured with adipose-derived SVFs from male (M group) and female (F group) individuals under oxidative stress conditions. The expression of several inflammatory (interleukin (IL)-33) and angiogenetic (platelet-derived growth factor (PDGF)) factors differed dramatically between male and female donors. Anti-inflammatory and pro-angiogenetic responses were observed in HUVECs co-cultured with SVFs under oxidative stress conditions, and these characteristics may exhibit partially differential effects according to gender. Using network analysis, we showed that co-culturing HUVECs with SVFs ameliorated pyroptosis/apoptosis via an increase in oxidative stress. Activation of caspase-1 and IL-1B was significantly altered in HUVECs co-cultured with SVFs from female donors. These findings regarding gender-dimorphic regulation of adipose-derived SVFs provide valuable information that can be used for evidence-based gender-specific clinical treatment of SVF transplantation for understanding of cardiovascular disease, allowing for the development of additional treatment. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Ivyspring International Publisher | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF MEDICAL SCIENCES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adipose Tissue / cytology | - |
dc.subject.MESH | Adipose Tissue / metabolism | - |
dc.subject.MESH | Apoptosis / genetics | - |
dc.subject.MESH | Cell Differentiation | - |
dc.subject.MESH | Cell Lineage / genetics | - |
dc.subject.MESH | Coculture Techniques | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Human Umbilical Vein Endothelial Cells | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Inflammation / genetics* | - |
dc.subject.MESH | Inflammation / pathology | - |
dc.subject.MESH | Interleukin-33 / genetics | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Neovascularization, Pathologic / genetics* | - |
dc.subject.MESH | Neovascularization, Pathologic / pathology | - |
dc.subject.MESH | Obesity / genetics* | - |
dc.subject.MESH | Obesity / pathology | - |
dc.subject.MESH | Oxidative Stress / genetics* | - |
dc.subject.MESH | Platelet-Derived Growth Factor | - |
dc.subject.MESH | Reactive Oxygen Species / metabolism | - |
dc.subject.MESH | Receptors, Platelet-Derived Growth Factor / genetics | - |
dc.subject.MESH | Sex Characteristics | - |
dc.subject.MESH | Stromal Cells / cytology* | - |
dc.subject.MESH | Stromal Cells / metabolism | - |
dc.title | Gender-dimorphic effects of adipose-derived stromal vascular fractions on HUVECs exposed to oxidative stress | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Others | - |
dc.contributor.googleauthor | Soyeon Lim | - |
dc.contributor.googleauthor | Il-Kwon Kim | - |
dc.contributor.googleauthor | Jung-Won Choi | - |
dc.contributor.googleauthor | Hyang-Hee Seo | - |
dc.contributor.googleauthor | Kyu Hee Lim | - |
dc.contributor.googleauthor | Seahyoung Lee | - |
dc.contributor.googleauthor | Hoon-Bum Lee | - |
dc.contributor.googleauthor | Sang Woo Kim | - |
dc.contributor.googleauthor | Ki-Chul Hwang | - |
dc.identifier.doi | 10.7150/ijms.19998 | - |
dc.relation.journalcode | J02917 | - |
dc.identifier.eissn | 1449-1907 | - |
dc.identifier.pmid | 28824330 | - |
dc.subject.keyword | Angiogenesis | - |
dc.subject.keyword | Gender | - |
dc.subject.keyword | HUVECs | - |
dc.subject.keyword | Human adipose-derived stromal vascular fractions | - |
dc.subject.keyword | Inflammation | - |
dc.subject.keyword | Oxidative stress | - |
dc.citation.volume | 14 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 911 | - |
dc.citation.endPage | 919 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF MEDICAL SCIENCES, Vol.14(9) : 911-919, 2017-07 | - |
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