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Abl Tyrosine Kinase Regulates Hepatitis C Virus Entry

Authors
 Saehong Min  ;  Yun-Sook Lim  ;  Dongjo Shin  ;  Chorong Park  ;  Jae-Bong Park  ;  Seungtaek Kim  ;  Marc P Windisch  ;  Soon B Hwang 
Citation
 FRONTIERS IN MICROBIOLOGY, Vol.8 : 1129, 2017-06 
Journal Title
FRONTIERS IN MICROBIOLOGY
Issue Date
2017-06
Keywords
Abl tyrosine kinase ; HCV entry ; hepatitis C virus ; host factor ; tyrosine kinase- inhibitor ; viral propagation
Abstract
Abl is a central regulator of multiple cellular processes controlling actin dynamics, proliferation, and differentiation. Here, we showed that knockdown of Abl impaired hepatitis C virus (HCV) propagation. Treatment of Abl tyrosine kinase-specific inhibitor, imatinib and dasatinib, also significantly decreased HCV RNA and protein levels in HCV-infected cells. We showed that both imatinib and dasatinib selectively inhibited HCV infection at the entry step of HCV life cycle, suggesting that Abl kinase activity may be necessary for HCV entry. Using HCV pseudoparticle infection assays, we verified that Abl is required for viral entry. By employing transferrin uptake and immunofluorescence assays, we further demonstrated that Abl was involved in HCV entry at a clathrin-mediated endocytosis step. These data suggest that Abl may represent a novel host factor for HCV entry.
Files in This Item:
T992017133.pdf Download
DOI
10.3389/fmicb.2017.01129
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
Yonsei Authors
Kim, Seung Taek(김승택)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/195701
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