Cited 63 times in
Centrifugal Lithography: Self-Shaping of Polymer Microstructures Encapsulating Biopharmaceutics by Centrifuging Polymer Drops
DC Field | Value | Language |
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dc.contributor.author | 조상래 | - |
dc.date.accessioned | 2023-08-09T02:31:45Z | - |
dc.date.available | 2023-08-09T02:31:45Z | - |
dc.date.issued | 2017-10 | - |
dc.identifier.issn | 2192-2640 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/195605 | - |
dc.description.abstract | Polymeric microstructures encapsulating biopharmaceutics must be fabricated in a controlled environment to preserve the biological activity. There is increasing demand for simple methods designed to preserve the biological activity by utilizing the natural properties of polymers. Here, the paper shows that centrifugal lithography (CL) can be used for the fabrication of such microstructures in a single centrifugation, by engineering the self-shaping properties of hyaluronic acid (HA). In this method, HA drops are self-shaped into hourglass-microstructures to produce two dissolving microneedles (DMN), which facilitate transdermal delivery via implantation on the skin. In addition, tuberculin purified protein derivatives are encapsulated into HA DMNs under refrigerated conditions (4 °C) during CL. Therefore, the tuberculin skin test (TST) with the DMNs indicates minimal damage, as opposed to the case of TST with traditional hypodermic needles. These findings on the fabrication of polymeric microstructures with biopharmaceutics may trigger the development of various biomedical devices and therapies. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Wiley-VCH | - |
dc.relation.isPartOf | ADVANCED HEALTHCARE MATERIALS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Capsules / chemical synthesis* | - |
dc.subject.MESH | Centrifugation | - |
dc.subject.MESH | Drug Compounding / methods* | - |
dc.subject.MESH | Hyaluronic Acid | - |
dc.subject.MESH | Materials Testing | - |
dc.subject.MESH | Microinjections / instrumentation* | - |
dc.subject.MESH | Needles | - |
dc.subject.MESH | Particle Size | - |
dc.subject.MESH | Pharmaceutical Preparations / administration & dosage* | - |
dc.subject.MESH | Pharmaceutical Preparations / chemistry* | - |
dc.subject.MESH | Stereolithography* | - |
dc.subject.MESH | Tuberculin Test / instrumentation* | - |
dc.subject.MESH | Viscosity | - |
dc.title | Centrifugal Lithography: Self-Shaping of Polymer Microstructures Encapsulating Biopharmaceutics by Centrifuging Polymer Drops | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Microbiology (미생물학교실) | - |
dc.contributor.googleauthor | Huisuk Yang | - |
dc.contributor.googleauthor | Suyong Kim | - |
dc.contributor.googleauthor | Geonwoo Kang | - |
dc.contributor.googleauthor | Shayan F Lahiji | - |
dc.contributor.googleauthor | Mingyu Jang | - |
dc.contributor.googleauthor | Young Mi Kim | - |
dc.contributor.googleauthor | Jae-Myung Kim | - |
dc.contributor.googleauthor | Sang-Nae Cho | - |
dc.contributor.googleauthor | Hyungil Jung | - |
dc.identifier.doi | 10.1002/adhm.201700326 | - |
dc.contributor.localId | A03824 | - |
dc.relation.journalcode | J00042 | - |
dc.identifier.eissn | 2192-2659 | - |
dc.identifier.pmid | 28703882 | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/10.1002/adhm.201700326 | - |
dc.subject.keyword | biopharmaceutics | - |
dc.subject.keyword | centrifugal lithography | - |
dc.subject.keyword | microneedles | - |
dc.subject.keyword | self-shaping | - |
dc.contributor.alternativeName | Cho, Sang Nae | - |
dc.contributor.affiliatedAuthor | 조상래 | - |
dc.citation.volume | 6 | - |
dc.citation.number | 19 | - |
dc.citation.startPage | 1700326 | - |
dc.identifier.bibliographicCitation | ADVANCED HEALTHCARE MATERIALS, Vol.6(19) : 1700326, 2017-10 | - |
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