Cited 4 times in
Involvement of PI3K and PKA pathways in mouse tongue epithelial differentiation
DC Field | Value | Language |
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dc.contributor.author | 조성원 | - |
dc.date.accessioned | 2023-08-09T02:31:22Z | - |
dc.date.available | 2023-08-09T02:31:22Z | - |
dc.date.issued | 2017-01 | - |
dc.identifier.issn | 0065-1281 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/195600 | - |
dc.description.abstract | In mice, tongue epithelial differentiation is mainly regulated by the interactions among various signalling molecules including Fgf signalling pathways. However, the subsequent signalling modulations for epithelial maturation, initiated by Fgf signalling, remain to be elucidated. Therefore, we employed an in vitro tongue organ cultivation system along with the applications of various pharmacological inhibitors against the intracellular signalling molecules of Fgf signalling pathways, including H89, LY294002, PD98059, and U0126. Following treatments with LY294002 and H89, inhibitors for PI3K and PKA, respectively, the decreased thickness of the tongue epithelium was observed along with the alteration in cell proliferative and apoptotic patterns. Meanwhile, cultivated tongues treated with MEK inhibitor U0126 or PD98059 showed significantly decreased cell proliferation in the tongue epithelium and the mesenchyme. Based on these results, we suggest that the tongue epithelium is differentiated into multiple epithelial cell layers via the PI3K and PKA pathways in tissue-specific manner during the epithelial-mesenchymal interactions. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | German, English | - |
dc.publisher | Jena Gustav Fischer Verlag | - |
dc.relation.isPartOf | ACTA HISTOCHEMICA | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Butadienes / pharmacology | - |
dc.subject.MESH | Cell Differentiation / drug effects | - |
dc.subject.MESH | Cell Proliferation / drug effects | - |
dc.subject.MESH | Chromones / pharmacology | - |
dc.subject.MESH | Cyclic AMP-Dependent Protein Kinases / antagonists & inhibitors | - |
dc.subject.MESH | Cyclic AMP-Dependent Protein Kinases / genetics | - |
dc.subject.MESH | Cyclic AMP-Dependent Protein Kinases / metabolism* | - |
dc.subject.MESH | Embryo, Mammalian | - |
dc.subject.MESH | Epithelial Cells / drug effects | - |
dc.subject.MESH | Epithelial Cells / metabolism | - |
dc.subject.MESH | Epithelial Cells / ultrastructure* | - |
dc.subject.MESH | Epithelial-Mesenchymal Transition / drug effects | - |
dc.subject.MESH | Fixatives | - |
dc.subject.MESH | Flavonoids / pharmacology | - |
dc.subject.MESH | Formaldehyde | - |
dc.subject.MESH | Gene Expression Regulation, Developmental | - |
dc.subject.MESH | Isoquinolines / pharmacology | - |
dc.subject.MESH | Ki-67 Antigen / genetics | - |
dc.subject.MESH | Ki-67 Antigen / metabolism | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred ICR | - |
dc.subject.MESH | Morpholines / pharmacology | - |
dc.subject.MESH | Nitriles / pharmacology | - |
dc.subject.MESH | Organ Culture Techniques | - |
dc.subject.MESH | Paraffin Embedding | - |
dc.subject.MESH | Phosphatidylinositol 3-Kinases / genetics | - |
dc.subject.MESH | Phosphatidylinositol 3-Kinases / metabolism* | - |
dc.subject.MESH | Phosphoinositide-3 Kinase Inhibitors | - |
dc.subject.MESH | Polymers | - |
dc.subject.MESH | Signal Transduction* | - |
dc.subject.MESH | Sulfonamides / pharmacology | - |
dc.subject.MESH | Tongue / drug effects | - |
dc.subject.MESH | Tongue / growth & development | - |
dc.subject.MESH | Tongue / metabolism | - |
dc.subject.MESH | Tongue / ultrastructure* | - |
dc.title | Involvement of PI3K and PKA pathways in mouse tongue epithelial differentiation | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Dept. of Oral Biology (구강생물학교실) | - |
dc.contributor.googleauthor | Jae-Kwang Jung | - |
dc.contributor.googleauthor | Hye-In Jung | - |
dc.contributor.googleauthor | Sanjiv Neupane | - |
dc.contributor.googleauthor | Ki-Rim Kim | - |
dc.contributor.googleauthor | Ji-Youn Kim | - |
dc.contributor.googleauthor | Hitoshi Yamamoto | - |
dc.contributor.googleauthor | Sung-Won Cho | - |
dc.contributor.googleauthor | Youngkyun Lee | - |
dc.contributor.googleauthor | Hong-In Shin | - |
dc.contributor.googleauthor | Wern-Joo Sohn | - |
dc.contributor.googleauthor | Jae-Young Kim | - |
dc.identifier.doi | 10.1016/j.acthis.2016.11.013 | - |
dc.contributor.localId | A03837 | - |
dc.relation.journalcode | J04460 | - |
dc.identifier.eissn | 1618-0372 | - |
dc.identifier.pmid | 27939449 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0065128116300745 | - |
dc.subject.keyword | Epithelial differentiation | - |
dc.subject.keyword | Keratinization | - |
dc.subject.keyword | Multiple cell layer formation | - |
dc.subject.keyword | PI3K | - |
dc.subject.keyword | PKA | - |
dc.subject.keyword | Tongue barrier formation | - |
dc.contributor.alternativeName | Cho, Sung Won | - |
dc.contributor.affiliatedAuthor | 조성원 | - |
dc.citation.volume | 119 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 92 | - |
dc.citation.endPage | 98 | - |
dc.identifier.bibliographicCitation | ACTA HISTOCHEMICA, Vol.119(1) : 92-98, 2017-01 | - |
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