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Prognostic factors of breast phyllodes tumors

Authors
 Eunah Shin  ;  Ja Seung Koo 
Citation
 HISTOLOGY AND HISTOPATHOLOGY, Vol.38(8) : 865-878, 2023-08 
Journal Title
HISTOLOGY AND HISTOPATHOLOGY
ISSN
 0213-3911 
Issue Date
2023-08
MeSH
Breast Neoplasms* ; Female ; Humans ; Neoplasm Recurrence, Local / pathology ; Phyllodes Tumor* / diagnosis ; Prognosis ; Retrospective Studies ; Stromal Cells / pathology
Abstract
Background: Phyllodes tumor (PT) is a relatively rare breast tumor, accounting for <1% of all breast tumors.

Main body: Adjuvant therapy with chemotherapy or radiation therapy, other than surgical excision, has not been established yet. PT, similar to other breast tumors, is classified as benign, borderline, and malignant according to the World Health Organization classification system, depending on stromal cellularity, stromal atypia, mitotic activity, stromal overgrowth, and tumor border. However, this histological grading system cannot effectively or fully reflect the clinical prognosis of PT. Several studies have investigated prognostic factors for PT as some PTs recur or metastasize to distant sites, and thus, prediction of prognosis is clinically imperative.

Conclusion: This review discusses clinicopathological factors, immunohistochemical markers, and molecular factors that have been investigated in previous studies to have an impact on the clinical prognosis of PT.

©The Author(s) 2023. Open Access. This article is licensed under a Creative Commons CC-BY International License.
Full Text
https://www.hh.um.es/Abstracts/Vol_38/38_8/38_8_865.htm
DOI
10.14670/HH-18-600
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Koo, Ja Seung(구자승) ORCID logo https://orcid.org/0000-0003-4546-4709
Shin, Eunah(신은아)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/195591
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