Cited 1 times in
Association of trabecular meshwork height with steroid-induced ocular hypertension
DC Field | Value | Language |
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dc.contributor.author | 김찬윤 | - |
dc.contributor.author | 배형원 | - |
dc.contributor.author | 최웅락 | - |
dc.date.accessioned | 2023-07-25T04:55:56Z | - |
dc.date.available | 2023-07-25T04:55:56Z | - |
dc.date.issued | 2023-06 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/195581 | - |
dc.description.abstract | It is important to identify at-risk patients prior to administering steroid injections to prevent avoidable irreversible blindness inducted by steroid-induced ocular hypertension (SIOH). We aimed to investigate the association of SIOH following intravitreal dexamethasone implantation (OZURDEX) using anterior segment optical coherence tomography (AS-OCT). We conducted a retrospective case control study to assess the association between trabecular meshwork and SIOH. A total of 102 eyes that underwent both AS-OCT and intravitreal dexamethasone implant injection were divided into the post-steroid ocular hypertension and normal intraocular pressure groups. Ocular parameters that can contribute to intraocular pressure were measured using AS-OCT. Univariable logistic regression analysis was used to calculate the odds ratio of the SIOH and significant variables were further analyzed using a multivariable model. Trabecular meshwork (TM) height was significantly shorter in the ocular hypertension group (716.13 ± 80.55 μm) than that in the normal intraocular pressure group (784.27 ± 82.33 μm) (p < 0.001). The receiver operating characteristic curve technique analysis showed that the optimal cut-off of ≥ 802.13 μm for TM height specificity was 96.2%, and TM height with < 646.75 μm had a sensitivity of 94.70%. The odds ratio of the association was 0.990 (p = 0.001). TM height was identified as a newly observed association with SIOH. TM height can be assessed using AS-OCT, with acceptable sensitivity and specificity. Caution must be exercised while injecting steroids in patients with short TM height (especially < 646.75 μm) as it may cause SIOH and irreversible blindness. © 2023. The Author(s). | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Blindness | - |
dc.subject.MESH | Case-Control Studies | - |
dc.subject.MESH | Dexamethasone / adverse effects | - |
dc.subject.MESH | Glaucoma* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Intraocular Pressure | - |
dc.subject.MESH | Ocular Hypertension* / chemically induced | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Trabecular Meshwork | - |
dc.title | Association of trabecular meshwork height with steroid-induced ocular hypertension | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Ophthalmology (안과학교실) | - |
dc.contributor.googleauthor | Won Jeong Cho | - |
dc.contributor.googleauthor | Yitak Kim | - |
dc.contributor.googleauthor | Jung Dong Kim | - |
dc.contributor.googleauthor | Eun Woo Kim | - |
dc.contributor.googleauthor | Hyoung Won Bae | - |
dc.contributor.googleauthor | Chan Yun Kim | - |
dc.contributor.googleauthor | Wungrak Choi | - |
dc.identifier.doi | 10.1038/s41598-023-36329-4 | - |
dc.contributor.localId | A01035 | - |
dc.contributor.localId | A01814 | - |
dc.contributor.localId | A04123 | - |
dc.relation.journalcode | J02646 | - |
dc.identifier.eissn | 2045-2322 | - |
dc.identifier.pmid | 37277443 | - |
dc.contributor.alternativeName | Kim, Chan Yun | - |
dc.contributor.affiliatedAuthor | 김찬윤 | - |
dc.contributor.affiliatedAuthor | 배형원 | - |
dc.contributor.affiliatedAuthor | 최웅락 | - |
dc.citation.volume | 13 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 9143 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, Vol.13(1) : 9143, 2023-06 | - |
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