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Effects of Androgen Treatment on Growth in Patients with 5-α-Reductase Type 2 Deficiency

 Hae In Lee  ;  Sujin Kim  ;  Sang-Woon Kim  ;  Myeongseob Lee  ;  Kyungchul Song  ;  Junghwan Suh  ;  Yong Seung Lee  ;  Hyun Wook Chae  ;  Ho-Seong Kim  ;  Sangwon Han  ;  Ahreum Kwon 
 JOURNAL OF PERSONALIZED MEDICINE, Vol.13(6) : 992, 2023-06 
Journal Title
Issue Date
5-α-reductase type 2 deficiency ; bone age ; dihydrotestosterone ; standard deviation score ; testosterone enanthate
Background: Patients with 5-α-reductase type 2 deficiency (5αRD2) require androgen treatment for the growth of normal male external genitalia. Since limited research has been conducted on the effects of androgen treatment on height in individuals with 5αRD2, we investigated the effect of androgen treatment on bone age (BA) and the height status in children with 5αRD2.

Methods: Of the 19 participants who were followed up for an average of 10.6 years, 12 received androgen treatment. BA and height standard deviation scores (SDS) were compared between the treatment and non-treatment groups, as well as between the dihydrotestosterone (DHT) and testosterone enanthate (TE) treatment groups.

Results: Despite the above-average height of the 19 patients with 5αRD2, the height SDS relative to BA (htSDS-BA) was below average, particularly in the androgen treatment group. DHT treatment did not lead to an increase in BA or htSDS-BA, whereas TE treatment resulted in BA advancement and decreased htSDS-BA, especially in the prepubertal period.

Conclusions: DHT treatment is more favorable for height than TE treatment in patients with 5αRD2, particularly during the prepubertal period. Therefore, age and the type of androgen used should be carefully considered to minimize the risk of height reduction in these patient groups.
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1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Ah Reum(권아름) ORCID logo https://orcid.org/0000-0002-9692-2135
Kim, Sang Woon(김상운) ORCID logo https://orcid.org/0000-0002-5790-1948
Kim, Su Jin(김수진) ORCID logo https://orcid.org/0000-0003-0907-9213
Kim, Ho Seong(김호성) ORCID logo https://orcid.org/0000-0003-1135-099X
Suh, Junghwan(서정환) ORCID logo https://orcid.org/0000-0002-2092-2585
Song, Kyungchul(송경철) ORCID logo https://orcid.org/0000-0002-8497-5934
Lee, Myeongseob(이명섭) ORCID logo https://orcid.org/0000-0001-7055-3100
Lee, Yong Seung(이용승) ORCID logo https://orcid.org/0000-0003-3778-9888
Chae, Hyun Wook(채현욱) ORCID logo https://orcid.org/0000-0001-5016-8539
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