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In-stent radiofrequency ablation with uncovered metal stent placement for tumor ingrowth/overgrowth causing self-expandable metal stent occlusion in distal malignant biliary obstruction: multicenter propensity score-matched study

 Namyoung Park  ;  Min Kyu Jung  ;  Eui Joo Kim  ;  Woo Hyun Paik  ;  Jae Hee Cho 
 GASTROINTESTINAL ENDOSCOPY, Vol.97(4) : 694-703.e2, 2023-04 
Journal Title
Issue Date
Bile Duct Neoplasms* / complications ; Bile Duct Neoplasms* / surgery ; Cholestasis* / etiology ; Cholestasis* / surgery ; Humans ; Metals ; Neoplasms* / complications ; Propensity Score ; Radiofrequency Ablation* / adverse effects ; Retrospective Studies ; Self Expandable Metallic Stents* / adverse effects ; Stents / adverse effects ; Treatment Outcome
Background and aims: In patients with unresectable malignant biliary obstruction (MBO), endoscopic drainage with a self-expandable metal stent (SEMS) is a well-established treatment, but stent patency is limited. This study aimed to evaluate the efficacy of in-stent radiofrequency ablation (IS-RFA) followed by uncovered SEMS placement for the management of occluded SEMSs.

Methods: From 2016 to 2020, 48 patients with recurrent biliary obstruction due to tumor ingrowth or overgrowth after SEMS placement for pancreatobiliary cancer in 3 tertiary hospitals were analyzed. For distal MBO, patients in the RFA group were treated with IS-RFA and uncovered SEMS placement, and those in the control group were treated with uncovered SEMS placement alone. Patients in both groups were matched on the basis of propensity scores in a 1:1 ratio.

Results: The median time to recurrent biliary obstruction (TRBO) was 117 days in the RFA group and 82.5 days in the control group (P = .029). No significant differences in median overall survival were detected between the 2 groups (170 days vs 72 days; P = .902). No significant adverse events were reported after the second SEMS placement in either group, but 2 cases of mild cholangitis were reported in the control group. Ablation was interrupted in 5 patients (35.7%) of the RFA group owing to in-stent contact, but sufficient ablative energy was delivered in the majority of the patients (92.9%) after IS-RFA was repeated in the same session.

Conclusions: IS-RFA followed by an uncovered SEMS is safe and feasible and may improve TRBO as a stent revision for occluded SEMSs in pancreatobiliary cancer.

Copyright © 2023 American Society for Gastrointestinal Endoscopy. Published by Elsevier Inc. All rights reserved.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Cho, Jae Hee(조재희) ORCID logo https://orcid.org/0000-0003-4174-0091
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