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Corticosteroid-Antibiotic Interactions in Bacteria that Cause Corneal Infection
DC Field | Value | Language |
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dc.contributor.author | 김태임 | - |
dc.date.accessioned | 2023-07-12T03:05:45Z | - |
dc.date.available | 2023-07-12T03:05:45Z | - |
dc.date.issued | 2023-05 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/195495 | - |
dc.description.abstract | Purpose: Although a comprehensive knowledge of antibiotic/corticosteroid combinations is essential for the appropriate treatment of eye infections, the impact of their co-administration has not been well studied to date. A systematic pharmacodynamic/pharmacokinetic study to determine the effects of cotreatment with various antibiotics and corticosteroids was conducted. Methods: Four bacterial strains, seven antibiotics, and four corticosteroids were used in the analyses. Drug interactions were evaluated by considering antibacterial effects with a checkerboard assay and intracellular concentrations in human corneal epithelial cells. Results: The drug combinations that showed the most stable effects against Pseudomonas aeruginosa was levofloxacin-prednisolone. Stable combinations against the three types of Gram-positive bacteria were neomycin-prednisolone, ofloxacin-dexamethasone, ofloxacin-prednisolone, and polymyxin-dexamethasone. The cellular concentrations were changed for the gatifloxacin-fluorometholone, moxifloxacin-fluorometholone, tobramycin-dexamethasone, and tobramycin-prednisolone combinations. Conclusions: Loteprednol and fluorometholone reduced the antibacterial effects of all of the tested antibiotics in this study. Dexamethasone and prednisolone showed various effects in this regard, depending on the co-administered antibiotic. Prior knowledge of specific antibiotic/corticosteroid interactions provides valuable information to clinical practitioners by combining data on the antibacterial and intracellular uptake effects of their co-administration. Translational relevance: When using antibiotics and corticosteroids, drug combinations can be selected by referring to the results of this study. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Association for Research in Vision and Ophthalmology | - |
dc.relation.isPartOf | TRANSLATIONAL VISION SCIENCE & TECHNOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adrenal Cortex Hormones / pharmacology | - |
dc.subject.MESH | Adrenal Cortex Hormones / therapeutic use | - |
dc.subject.MESH | Anti-Bacterial Agents / pharmacology | - |
dc.subject.MESH | Anti-Bacterial Agents / therapeutic use | - |
dc.subject.MESH | Bacteria | - |
dc.subject.MESH | Dexamethasone / pharmacology | - |
dc.subject.MESH | Dexamethasone / therapeutic use | - |
dc.subject.MESH | Drug Combinations | - |
dc.subject.MESH | Eye Infections, Bacterial* / drug therapy | - |
dc.subject.MESH | Eye Infections, Bacterial* / microbiology | - |
dc.subject.MESH | Fluorometholone / pharmacology | - |
dc.subject.MESH | Fluorometholone / therapeutic use | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Keratitis* / drug therapy | - |
dc.subject.MESH | Levofloxacin / pharmacology | - |
dc.subject.MESH | Levofloxacin / therapeutic use | - |
dc.subject.MESH | Prednisolone / pharmacology | - |
dc.subject.MESH | Prednisolone / therapeutic use | - |
dc.subject.MESH | Tobramycin / pharmacology | - |
dc.subject.MESH | Tobramycin / therapeutic use | - |
dc.title | Corticosteroid-Antibiotic Interactions in Bacteria that Cause Corneal Infection | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Ophthalmology (안과학교실) | - |
dc.contributor.googleauthor | Hun Lee | - |
dc.contributor.googleauthor | So Myoung Kim | - |
dc.contributor.googleauthor | Md Intazur Rahaman | - |
dc.contributor.googleauthor | Dong Ju Kang | - |
dc.contributor.googleauthor | Changhyun Kim | - |
dc.contributor.googleauthor | Tae-Im Kim | - |
dc.contributor.googleauthor | So Won Kim | - |
dc.identifier.doi | 10.1167/tvst.12.5.16 | - |
dc.contributor.localId | A01080 | - |
dc.relation.journalcode | J04101 | - |
dc.identifier.eissn | 2164-2591 | - |
dc.identifier.pmid | 37184498 | - |
dc.contributor.alternativeName | Kim, Tae Im | - |
dc.contributor.affiliatedAuthor | 김태임 | - |
dc.citation.volume | 12 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 16 | - |
dc.identifier.bibliographicCitation | TRANSLATIONAL VISION SCIENCE & TECHNOLOGY, Vol.12(5) : 16, 2023-05 | - |
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