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Peripapillary choroidal microvasculature dropout is associated with poor prognosis in optic neuritis

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dc.contributor.author김찬윤-
dc.contributor.author배형원-
dc.contributor.author이상엽-
dc.contributor.author이지혜-
dc.contributor.author최웅락-
dc.contributor.author박성은-
dc.date.accessioned2023-07-12T02:44:58Z-
dc.date.available2023-07-12T02:44:58Z-
dc.date.issued2023-04-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/195386-
dc.description.abstractPurpose: To identify peripapillary choroidal microvasculature dropout (MvD) in eyes with optic neuritis and its association with longitudinal changes in retinal nerve fiber layer (RNFL) and ganglion cell-inner plexiform layer (GCIP) thicknesses following diagnosis. Methods: A total of 48 eyes with optic neuritis was evaluated to identify the presence of peripapillary choroidal MvD, defined as a focal capillary loss with no visible microvascular network in choroidal layer, using optical coherence tomography (OCT) angiography (OCTA). Patients were divided based on the presence of MvD. OCT and standard automated perimetry (SAP) conducted at 1, 3 and 6 months follow-up were analyzed. Results: MvD was identified in 20 of 48 eyes (41.7%) with optic neuritis. MvD was most commonly found in the temporal quadrant (85.0%), and peripapillary retinal vessel density in the temporal quadrant was significantly lower in eyes with MvD (P = 0.012). At 6 months follow-up, optic neuritis eyes with MvD showed significantly thinner GCIP in superior, superotemporal, inferior and inferotemporal sectors (P<0.05). No significant difference was noted in SAP parameters. The presence of MvD was significantly associated with thinner global GCIP thickness at 6 months follow-up (OR 0.909, 95% CI 0.833-0.992, P = 0.032). Conclusion: Optic neuritis showed peripapillary choroidal microvascular impairment in the form of MvD. MvD was associated with structural deterioration at macular GCIP. Further studies are necessary to identify the causal relationship between microvascular impairment and retinal nerve fiber layer damage in optic neuritis. Copyright: © 2023 Lee et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherPublic Library of Science-
dc.relation.isPartOfPLOS ONE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHHumans-
dc.subject.MESHMicrovessels / diagnostic imaging-
dc.subject.MESHNerve Fibers-
dc.subject.MESHOptic Disk* / blood supply-
dc.subject.MESHOptic Disk* / diagnostic imaging-
dc.subject.MESHOptic Neuritis* / diagnostic imaging-
dc.subject.MESHPrognosis-
dc.subject.MESHRetinal Diseases*-
dc.subject.MESHRetinal Ganglion Cells-
dc.subject.MESHTomography, Optical Coherence / methods-
dc.subject.MESHVisual Fields-
dc.titlePeripapillary choroidal microvasculature dropout is associated with poor prognosis in optic neuritis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Ophthalmology (안과학교실)-
dc.contributor.googleauthorJihei Sara Lee-
dc.contributor.googleauthorSungeun Park-
dc.contributor.googleauthorSung Sik Kim-
dc.contributor.googleauthorChan Yun Kim-
dc.contributor.googleauthorWungrak Choi-
dc.contributor.googleauthorSang Yeop Lee-
dc.contributor.googleauthorHyoung Won Bae-
dc.identifier.doi10.1371/journal.pone.0285017-
dc.contributor.localIdA01035-
dc.contributor.localIdA01814-
dc.contributor.localIdA02820-
dc.contributor.localIdA06116-
dc.contributor.localIdA04123-
dc.relation.journalcodeJ02540-
dc.identifier.eissn1932-6203-
dc.identifier.pmid37104301-
dc.contributor.alternativeNameKim, Chan Yun-
dc.contributor.affiliatedAuthor김찬윤-
dc.contributor.affiliatedAuthor배형원-
dc.contributor.affiliatedAuthor이상엽-
dc.contributor.affiliatedAuthor이지혜-
dc.contributor.affiliatedAuthor최웅락-
dc.citation.volume18-
dc.citation.number4-
dc.citation.startPagee0285017-
dc.identifier.bibliographicCitationPLOS ONE, Vol.18(4) : e0285017, 2023-04-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers

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