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Melatonin and Prostate Cancer: Anti-tumor Roles and Therapeutic Application

Authors
 Mark F Megerian  ;  Jae Seok Kim  ;  Jad Badreddine  ;  Sung Hwi Hong  ;  Lee E Ponsky  ;  Jae Il Shin  ;  Ramy Abou Ghayda 
Citation
 AGING AND DISEASE, Vol.14(3) : 840-857, 2023-06 
Journal Title
AGING AND DISEASE
Issue Date
2023-06
Abstract
Melatonin is an endogenous indoleamine that has been shown to inhibit tumor growth in laboratory models of prostate cancer. Prostate cancer risk has additionally been associated with exogenous factors that interfere with normal pineal secretory activity, including aging, poor sleep, and artificial light at night. Therefore, we aim to expand on the important epidemiological evidence, and to review how melatonin can impede prostate cancer. More specifically, we describe the currently known mechanisms of melatonin-mediated oncostasis in prostate cancer, including those that relate to the indolamine's ability to modulate metabolic activity, cell cycle progression and proliferation, androgen signaling, angiogenesis, metastasis, immunity and oxidative cell status, apoptosis, genomic stability, neuroendocrine differentiation, and the circadian rhythm. The outlined evidence underscores the need for clinical trials to determine the efficacy of supplemental, adjunct, and adjuvant melatonin therapy for the prevention and treatment of prostate cancer.
Files in This Item:
T202303004.pdf Download
DOI
10.14336/ad.2022.1010
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Shin, Jae Il(신재일) ORCID logo https://orcid.org/0000-0003-2326-1820
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/195361
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