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Epithelial plasticity enhances regeneration of committed taste receptor cells following nerve injury
DC Field | Value | Language |
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dc.contributor.author | 문석준 | - |
dc.contributor.author | 이동준 | - |
dc.contributor.author | 이종민 | - |
dc.contributor.author | 정한성 | - |
dc.date.accessioned | 2023-07-12T02:30:29Z | - |
dc.date.available | 2023-07-12T02:30:29Z | - |
dc.date.issued | 2023-01 | - |
dc.identifier.issn | 1226-3613 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/195329 | - |
dc.description.abstract | Taste receptor cells are taste bud epithelial cells that are dependent upon the innervating nerve for continuous renewal and are maintained by resident tissue stem/progenitor cells. Transection of the innervating nerve causes degeneration of taste buds and taste receptor cells. However, a subset of the taste receptor cells is maintained without nerve contact after glossopharyngeal nerve transection in the circumvallate papilla in adult mice. Here, we revealed that injury caused by glossopharyngeal nerve transection triggers the remaining differentiated K8-positive taste receptor cells to dedifferentiate and acquire transient progenitor cell-like states during regeneration. Dedifferentiated taste receptor cells proliferate, express progenitor cell markers (K14, Sox2, PCNA) and form organoids in vitro. These data indicate that differentiated taste receptor cells can enter the cell cycle, acquire stemness, and participate in taste bud regeneration. We propose that dedifferentiated taste receptor cells in combination with stem/progenitor cells enhance the regeneration of taste buds following nerve injury. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isPartOf | EXPERIMENTAL AND MOLECULAR MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Epithelial Cells | - |
dc.subject.MESH | Glossopharyngeal Nerve Injuries* | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Stem Cells | - |
dc.subject.MESH | Taste | - |
dc.subject.MESH | Taste Buds* / metabolism | - |
dc.title | Epithelial plasticity enhances regeneration of committed taste receptor cells following nerve injury | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Dept. of Oral Biology (구강생물학교실) | - |
dc.contributor.googleauthor | Anish Ashok Adpaikar | - |
dc.contributor.googleauthor | Jong-Min Lee | - |
dc.contributor.googleauthor | Dong-Joon Lee | - |
dc.contributor.googleauthor | Hye-Yeon Cho | - |
dc.contributor.googleauthor | Hayato Ohshima | - |
dc.contributor.googleauthor | Seok Jun Moon | - |
dc.contributor.googleauthor | Han-Sung Jung | - |
dc.identifier.doi | 10.1038/s12276-022-00924-8 | - |
dc.contributor.localId | A01358 | - |
dc.contributor.localId | A02732 | - |
dc.contributor.localId | A04640 | - |
dc.contributor.localId | A03758 | - |
dc.relation.journalcode | J00860 | - |
dc.identifier.eissn | 2092-6413 | - |
dc.identifier.pmid | 36631663 | - |
dc.contributor.alternativeName | Moon, Seok Jun | - |
dc.contributor.affiliatedAuthor | 문석준 | - |
dc.contributor.affiliatedAuthor | 이동준 | - |
dc.contributor.affiliatedAuthor | 이종민 | - |
dc.contributor.affiliatedAuthor | 정한성 | - |
dc.citation.volume | 55 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 171 | - |
dc.citation.endPage | 182 | - |
dc.identifier.bibliographicCitation | EXPERIMENTAL AND MOLECULAR MEDICINE, Vol.55(1) : 171-182, 2023-01 | - |
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