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방광암세포주에서 IFN-γ의 효과
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박전한 | - |
dc.date.accessioned | 2023-07-12T00:30:00Z | - |
dc.date.available | 2023-07-12T00:30:00Z | - |
dc.date.issued | 1994-07 | - |
dc.identifier.issn | 0494-4747 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/195141 | - |
dc.description.abstract | The purpose of this study is to analyze the effects of IFN-r(interferon-r) on HLA-DR and ICAM-l(intercellular adhesion molecule 1) expression, a measure of cancer progression. We uses human bladder tumor cell lines of RT4(GI) and T24(GIII), a part of each type of cultured cells were treated by 200U/m IFN-r and divided into 3 groups( 24-hour, 48-hour, 72-hour) according to the time after the IFN-r treatment. Each cell was then indirectly immunofluorescence stained and analyzed using the Fluorescence Activated Cell Sorter(FACS). We founded that bladder cancer cells, when they are not treated by IFN-r, do not seem to show much HLA-DR constitutive expression. When bladder cancer cells are treated by IFN-r, the effects of IFN-r on HLA-DR expression rate seem to depend on the degree of differentiation of bladder cancer cells : well-differentiated bladder cancer cell shows higher HLA-DR expression rate when it is treated by IFN-r, while poorly-differentiated bladder cancer cell does not show much changes in HLA-DR expression rate even after it is treated by IFN-r. Bladder cancer cells of higher degree of malignancy show higher ICAM-1 constitutive expression rate and enhanced expression by IFN-r | - |
dc.description.statementOfResponsibility | open | - |
dc.language | Korean | - |
dc.publisher | 대한비뇨기과학회 | - |
dc.relation.isPartOf | KOREAN JOURNAL OF UROLOGY(대한비뇨기과학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | 방광암세포주에서 IFN-γ의 효과 | - |
dc.title.alternative | Effects of IFN-r on Human Bladder Tumor Cell Lines | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Microbiology (미생물학교실) | - |
dc.contributor.googleauthor | 박동수 | - |
dc.contributor.googleauthor | 이정림 | - |
dc.contributor.googleauthor | 박전한 | - |
dc.contributor.googleauthor | 이진무 | - |
dc.contributor.googleauthor | 김세종 | - |
dc.contributor.localId | A01641 | - |
dc.relation.journalcode | J02135 | - |
dc.contributor.alternativeName | Park, Jeon Han | - |
dc.contributor.affiliatedAuthor | 박전한 | - |
dc.citation.volume | 35 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 691 | - |
dc.citation.endPage | 696 | - |
dc.identifier.bibliographicCitation | Korean Journal of Urology (대한비뇨기과학회지), Vol.35(7) : 691-696, 1994-07 | - |
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