조기 진통 임신부의 양수내 일부 Cytokine 의 측정치 자궁내 감염과의 관련성에 관한 연구

Abstract

Subclincal instrauterine infection was suggested as a cause of idiopathic preterm labor. Four groups of 66 pregnant women were studied. Women in the midtrimester of pregnancy undergoing genetic amniocentesis were studied as a preterm without labor group. Women with preterm labor were also studied. Term pregnant women undergoing repeat cesarean section were included as a term without labor group Women with term labor group were also included in the study. Amniotic fluid was obtained through amniocentesis. The fluid was culturd for aerobic and anaerobic bacterias. After centrifugation an aliquot of amniotic fluid was frozen(-70 C) for futher analsis. Interleukin-1(IL-1) and interleukin-6(IL-6) levels were measured by hexokinase method. Placentas were examined for histologic choriamninitis after delivery. Only two women with term labor showed opsitive amniotic fluid culture. Glucose levels were lower in the amniotic fluid of erm pregnant women than perterm pregnant women. IL-1 level in the amniotic fluid were increased over 290 pg/ml in 2 case of term labor group. IL-6 were found in all samples of amniotic fluid. The levels were increased in the women having either preterm or term labor IL-6 levles in the amniotic fluid were proportionally increased according to the degree of the cervical dilatation. The results suggested that the increased level IL-6 was a resullt of labor and/or cervical dilatation rather than a cause of intrauterine infection evoking preterm labor. Histologic choriamnionits were increased in the placenta of both preterm labor. Histologic choriamnionits were increased in the placenta of both preterm labor group and term labor group. The incidence rates of histologic choreioamnionitis were not statistically different among groups.