Multivesicular liposome포장 cytarabine이 녹내장 여과 창상 치유에 미치는 영향

Abstract

In this study, multivesicular liposome-encapsulated cytarabine was injected subconjunctivally to observe the effects on wound healing, its complications, and the possibility of this method for decreasing frequency of injections. In normal rabbit eyes, subconjunctival injections of normal saline were administered daily for 7 days after filtering surgery in the control group. In the next group(group I), 2.5mg of cytarabine was given in the same manner as the control group. In another group(group Ⅱ) 2.5mg of cytarabine was given immediately after surgery and 3 days after surgery. The final group (group Ⅲ) was given multivesicular lipsome-encapsulated cytarabine containing 2.5mg of cytarabine in the same manner as Group Ⅱ. The IOP and histological change of the filtering site were evaluated at postoperative 1, 2, 4 , and 8 weeks. Complications were evaluated and recorded as follows: 1. In the control group, the filtering site became occluded within a week and the IOP was not significantly decreased. 2. In group I, the filtering site remained open and the IOP was significantly decreased for two weeks. 3. In group Ⅱ, the filtering site became occluded within a week, and the IOP was not significantly decreased. 4. In group Ⅲ, the filtering site remained open, and the IOP was siginficantly decreased for two weeks 5. There were no systemic complications, and intraocular complications were decreased with decreasing frequency of subconjunctival injection. In summary, the above results suggest that subconjunctival injection of multivesicular liposome-encapsulated cytarabine delays the frequency of injections and complications