Evolution of predictive and prognostic biomarkers in the treatment of advanced gastric cancer

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Authors: Nicole M Myer ; Kohei Shitara ; Hyun C Chung ; Florian Lordick ; Ronan J Kelly ; Zsolt Szabo ; Z Alexander Cao ; Stephen Leong ; David H Ilson ; Wilko Weichert

Citation: JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, Vol.148(8) : 2023-2043, 2022-08

MeSH: B7-H1 Antigen / metabolism ; Biomarkers, Tumor / metabolism ; Humans ; Microsatellite Instability ; Prognosis ; Stomach Neoplasms* / metabolism

Keywords: Biomarkers ; Gastric cancer ; Microsatellite instability ; Programmed death ligand 1 ; Tumor mutational burden

Abstract: Despite new therapeutic options, advanced gastric cancer remains associated with a poor prognosis compared with other cancers. Recent gains in the treatment of gastric cancer were accompanied by the identification of novel biomarkers associated with various cellular pathways and corresponding diagnostic technologies. It is expected that the standardization of clinical workflow and technological refinements in biomarker assessment will support greater personalization and further improve treatment outcomes. In this article, we review the current state of prognostic and predictive biomarkers in gastric cancer.

Appears in Collections:: 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

Yonsei Authors: Chung, Hyun Cheol(정현철) https://orcid.org/0000-0002-0920-9471

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YUHSpace: Evolution of predictive and prognostic biomarkers in the treatment of advanced gastric cancer