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Enhanced cross protection by hetero prime-boost vaccination with recombinant influenza viruses containing chimeric hemagglutinin-M2e epitopes

DC Field Value Language
dc.contributor.author성백린-
dc.date.accessioned2023-06-02T00:52:48Z-
dc.date.available2023-06-02T00:52:48Z-
dc.date.issued2022-01-
dc.identifier.issn0042-6822-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/194489-
dc.description.abstractAnnual repeat influenza vaccination raises concerns about protective efficacy against mismatched viruses. We investigated the impact of heterologous prime-boost vaccination on inducing cross protection by designing recombinant influenza viruses with chimeric hemagglutinin (HA) carrying M2 extracellular domains (M2e-HA). Heterologous prime-boost vaccination of C57BL/6 mice with M2e-HA chimeric virus more effectively induced M2e and HA stalk specific IgG antibodies correlating with cross protection than homologous prime-boost vaccination. Induction of M2e and HA stalk specific IgG antibodies was compromised in 1-year old mice, indicating significant aging effects on priming subdominant M2e and HA stalk IgG antibody responses. This study demonstrates that a heterologous prime-boost strategy with recombinant influenza virus expressing extra M2e epitopes provides more effective cross protection than homologous vaccination.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherAcademic Press-
dc.relation.isPartOfVIROLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAge Factors-
dc.subject.MESHAging / genetics-
dc.subject.MESHAging / immunology*-
dc.subject.MESHAnimals-
dc.subject.MESHAntibodies, Viral / biosynthesis*-
dc.subject.MESHAntigens, Viral / genetics-
dc.subject.MESHAntigens, Viral / immunology-
dc.subject.MESHCross Protection-
dc.subject.MESHFemale-
dc.subject.MESHHemagglutinin Glycoproteins, Influenza Virus / genetics*-
dc.subject.MESHHemagglutinin Glycoproteins, Influenza Virus / immunology-
dc.subject.MESHHumans-
dc.subject.MESHImmunization, Secondary / methods-
dc.subject.MESHImmunogenicity, Vaccine-
dc.subject.MESHImmunoglobulin G / biosynthesis*-
dc.subject.MESHInfluenza A Virus, H1N1 Subtype / immunology-
dc.subject.MESHInfluenza A Virus, H1N1 Subtype / pathogenicity-
dc.subject.MESHInfluenza A Virus, H3N2 Subtype / immunology-
dc.subject.MESHInfluenza A Virus, H3N2 Subtype / pathogenicity-
dc.subject.MESHInfluenza Vaccines / administration & dosage-
dc.subject.MESHInfluenza Vaccines / biosynthesis-
dc.subject.MESHInfluenza Vaccines / genetics*-
dc.subject.MESHInfluenza, Human / immunology-
dc.subject.MESHInfluenza, Human / prevention & control*-
dc.subject.MESHInfluenza, Human / virology-
dc.subject.MESHMice-
dc.subject.MESHMice, Inbred C57BL-
dc.subject.MESHModels, Molecular-
dc.subject.MESHOrthomyxoviridae Infections / immunology-
dc.subject.MESHOrthomyxoviridae Infections / prevention & control*-
dc.subject.MESHOrthomyxoviridae Infections / virology-
dc.subject.MESHRecombinant Fusion Proteins / chemistry-
dc.subject.MESHRecombinant Fusion Proteins / genetics-
dc.subject.MESHRecombinant Fusion Proteins / immunology-
dc.subject.MESHVaccination / methods-
dc.subject.MESHVaccines, Synthetic-
dc.subject.MESHViral Matrix Proteins / genetics-
dc.subject.MESHViral Matrix Proteins / immunology-
dc.titleEnhanced cross protection by hetero prime-boost vaccination with recombinant influenza viruses containing chimeric hemagglutinin-M2e epitopes-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Microbiology (미생물학교실)-
dc.contributor.googleauthorBo Ryoung Park-
dc.contributor.googleauthorJeeva Subbiah-
dc.contributor.googleauthorKi-Hye Kim-
dc.contributor.googleauthorYoung-Man Kwon-
dc.contributor.googleauthorJudy Oh-
dc.contributor.googleauthorMin-Chul Kim-
dc.contributor.googleauthorChong-Hyun Shin-
dc.contributor.googleauthorBaik Lin Seong-
dc.contributor.googleauthorSang-Moo Kang-
dc.identifier.doi10.1016/j.virol.2021.12.003-
dc.contributor.localIdA06211-
dc.relation.journalcodeJ02785-
dc.identifier.eissn1096-0341-
dc.identifier.pmid34929590-
dc.subject.keywordCross protection-
dc.subject.keywordLive attenuated virus-
dc.subject.keywordM2e-
dc.subject.keywordRecombinant influenza virus-
dc.contributor.alternativeNameSeong, Baik L-
dc.contributor.affiliatedAuthor성백린-
dc.citation.volume566-
dc.citation.startPage143-
dc.citation.endPage152-
dc.identifier.bibliographicCitationVIROLOGY, Vol.566 : 143-152, 2022-01-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
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