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Enhanced cross protection by hetero prime-boost vaccination with recombinant influenza viruses containing chimeric hemagglutinin-M2e epitopes

DC Field Value Language
dc.contributor.authorPark, Bo Ryoung-
dc.contributor.authorSubbiah, Jeeva-
dc.contributor.authorKim, Ki-Hye-
dc.contributor.authorKwon, Young-Man-
dc.contributor.authorOh, Judy-
dc.contributor.authorKim, Min-Chul-
dc.contributor.authorShin, Chong-Hyun-
dc.contributor.authorSeong, Baik Lin-
dc.contributor.authorKang, Sang-Moo-
dc.date.accessioned2023-06-02T00:52:48Z-
dc.date.available2023-06-02T00:52:48Z-
dc.date.created2023-03-28-
dc.date.issued2022-01-
dc.identifier.issn0042-6822-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/194489-
dc.description.abstractAnnual repeat influenza vaccination raises concerns about protective efficacy against mismatched viruses. We investigated the impact of heterologous prime-boost vaccination on inducing cross protection by designing recombinant influenza viruses with chimeric hemagglutinin (HA) carrying M2 extracellular domains (M2e-HA). Heterologous prime-boost vaccination of C57BL/6 mice with M2e-HA chimeric virus more effectively induced M2e and HA stalk specific IgG antibodies correlating with cross protection than homologous prime-boost vaccination. Induction of M2e and HA stalk specific IgG antibodies was compromised in 1-year old mice, indicating significant aging effects on priming subdominant M2e and HA stalk IgG antibody responses. This study demonstrates that a heterologous prime-boost strategy with recombinant influenza virus expressing extra M2e epitopes provides more effective cross protection than homologous vaccination.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherAcademic Press-
dc.relation.isPartOfVIROLOGY-
dc.relation.isPartOfVIROLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleEnhanced cross protection by hetero prime-boost vaccination with recombinant influenza viruses containing chimeric hemagglutinin-M2e epitopes-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Microbiology (미생물학교실)-
dc.contributor.googleauthorPark, Bo Ryoung-
dc.contributor.googleauthorSubbiah, Jeeva-
dc.contributor.googleauthorKim, Ki-Hye-
dc.contributor.googleauthorKwon, Young-Man-
dc.contributor.googleauthorOh, Judy-
dc.contributor.googleauthorKim, Min-Chul-
dc.contributor.googleauthorShin, Chong-Hyun-
dc.contributor.googleauthorSeong, Baik Lin-
dc.contributor.googleauthorKang, Sang-Moo-
dc.identifier.doi10.1016/j.virol.2021.12.003-
dc.relation.journalcodeJ02785-
dc.identifier.eissn1096-0341-
dc.identifier.pmid34929590-
dc.subject.keywordRecombinant influenza virus-
dc.subject.keywordLive attenuated virus-
dc.subject.keywordM2e-
dc.subject.keywordCross protection-
dc.contributor.alternativeNameSeong, Baik L-
dc.contributor.affiliatedAuthorSeong, Baik Lin-
dc.identifier.scopusid2-s2.0-85121432427-
dc.identifier.wosid000793137700003-
dc.citation.volume566-
dc.citation.startPage143-
dc.citation.endPage152-
dc.identifier.bibliographicCitationVIROLOGY, Vol.566 : 143-152, 2022-01-
dc.identifier.rimsid78174-
dc.type.rimsART-
dc.description.journalClass1-
dc.description.journalClass1-
dc.subject.keywordAuthorRecombinant influenza virus-
dc.subject.keywordAuthorLive attenuated virus-
dc.subject.keywordAuthorM2e-
dc.subject.keywordAuthorCross protection-
dc.subject.keywordPlusRESPIRATORY SYNCYTIAL VIRUS-
dc.subject.keywordPlusM2 EXTRACELLULAR DOMAINS-
dc.subject.keywordPlusREPEAT VACCINATION-
dc.subject.keywordPlusIMMUNE-RESPONSE-
dc.subject.keywordPlusEFFICACY-
dc.subject.keywordPlusECTODOMAIN-
dc.subject.keywordPlusVACCINES-
dc.subject.keywordPlusSTRAIN-
dc.subject.keywordPlusIMPACT-
dc.subject.keywordPlusBROAD-
dc.type.docTypeArticle-
dc.description.isOpenAccessY-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalWebOfScienceCategoryVirology-
dc.relation.journalResearchAreaVirology-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
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