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Dairy Intake and Parkinson's Disease: A Mendelian Randomization Study

Authors
 Cloé Domenighetti  ;  Pierre-Emmanuel Sugier  ;  Ashwin Ashok Kumar Sreelatha  ;  Claudia Schulte  ;  Sandeep Grover  ;  Océane Mohamed  ;  Berta Portugal  ;  Patrick May  ;  Dheeraj R Bobbili  ;  Milena Radivojkov-Blagojevic  ;  Peter Lichtner  ;  Andrew B Singleton  ;  Dena G Hernandez  ;  Connor Edsall  ;  George D Mellick  ;  Alexander Zimprich  ;  Walter Pirker  ;  Ekaterina Rogaeva  ;  Anthony E Lang  ;  Sulev Koks  ;  Pille Taba  ;  Suzanne Lesage  ;  Alexis Brice  ;  Jean-Christophe Corvol  ;  Marie-Christine Chartier-Harlin  ;  Eugénie Mutez  ;  Kathrin Brockmann  ;  Angela B Deutschländer  ;  Georges M Hadjigeorgiou  ;  Efthimos Dardiotis  ;  Leonidas Stefanis  ;  Athina Maria Simitsi  ;  Enza Maria Valente  ;  Simona Petrucci  ;  Stefano Duga  ;  Letizia Straniero  ;  Anna Zecchinelli  ;  Gianni Pezzoli  ;  Laura Brighina  ;  Carlo Ferrarese  ;  Grazia Annesi  ;  Andrea Quattrone  ;  Monica Gagliardi  ;  Hirotaka Matsuo  ;  Yusuke Kawamura  ;  Nobutaka Hattori  ;  Kenya Nishioka  ;  Sun Ju Chung  ;  Yun Joong Kim  ;  Pierre Kolber  ;  Bart P C van de Warrenburg  ;  Bastiaan R Bloem  ;  Jan Aasly  ;  Mathias Toft  ;  Lasse Pihlstrøm  ;  Leonor Correia Guedes  ;  Joaquim J Ferreira  ;  Soraya Bardien  ;  Jonathan Carr  ;  Eduardo Tolosa  ;  Mario Ezquerra  ;  Pau Pastor  ;  Monica Diez-Fairen  ;  Karin Wirdefeldt  ;  Nancy L Pedersen  ;  Caroline Ran  ;  Andrea C Belin  ;  Andreas Puschmann  ;  Clara Hellberg  ;  Carl E Clarke  ;  Karen E Morrison  ;  Manuela Tan  ;  Dimitri Krainc  ;  Lena F Burbulla  ;  Matt J Farrer  ;  Rejko Krüger  ;  Thomas Gasser  ;  Manu Sharma  ;  Alexis Elbaz 
Citation
 MOVEMENT DISORDERS, Vol.37(4) : 857-864, 2022-04 
Journal Title
MOVEMENT DISORDERS
ISSN
 0885-3185 
Issue Date
2022-04
MeSH
Dairy Products / adverse effects ; Female ; Genetic Predisposition to Disease / genetics ; Genome-Wide Association Study ; Humans ; Male ; Mendelian Randomization Analysis ; Parkinson Disease* / epidemiology ; Parkinson Disease* / genetics ; Polymorphism, Single Nucleotide / genetics ; Risk Factors
Keywords
dairy intake ; Parkinson's disease ; Mendelian randomization
Abstract
Background: Previous prospective studies highlighted dairy intake as a risk factor for Parkinson's disease (PD), particularly in men. It is unclear whether this association is causal or explained by reverse causation or confounding.

Objective: The aim is to examine the association between genetically predicted dairy intake and PD using two-sample Mendelian randomization (MR).

Methods: We genotyped a well-established instrumental variable for dairy intake located in the lactase gene (rs4988235) within the Courage-PD consortium (23 studies; 9823 patients and 8376 controls of European ancestry).

Results: Based on a dominant model, there was an association between genetic predisposition toward higher dairy intake and PD (odds ratio [OR] per one serving per day = 1.70, 95% confidence interval = 1.12-2.60, P = 0.013) that was restricted to men (OR = 2.50 [1.37-4.56], P = 0.003; P-difference with women = 0.029).

Conclusions: Using MR, our findings provide further support for a causal relationship between dairy intake and higher PD risk, not biased by confounding or reverse causation. Further studies are needed to elucidate the underlying mechanisms. © 2022 International Parkinson and Movement Disorder Society.
Full Text
https://movementdisorders.onlinelibrary.wiley.com/doi/10.1002/mds.28902
DOI
10.1002/mds.28902
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Yun Joong(김윤중) ORCID logo https://orcid.org/0000-0002-2956-1552
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/194425
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