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Comparison of a preservative-free nonsteroidal anti-inflammatory drug and preservative-free corticosteroid after uneventful cataract surgery: multicenter, randomized, evaluator-blinded clinical trial
DC Field | Value | Language |
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dc.contributor.author | 이형근 | - |
dc.date.accessioned | 2023-06-02T00:45:47Z | - |
dc.date.available | 2023-06-02T00:45:47Z | - |
dc.date.issued | 2022-06 | - |
dc.identifier.issn | 0886-3350 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/194407 | - |
dc.description.abstract | Purpose: To compare the efficacy of nonsteroidal anti-inflammatory drugs (NSAIDs) and steroidal eyedrops for inflammation management after cataract surgery using slitlamp indicators. Setting: 11 eye centers in South Korea. Design: Randomized prospective multicenter study with a blinded evaluator. Method: In 125 (250 eyes) patients who underwent cataract surgery, bromfenac sodium hydrate 0.1% (NSAID group) was applied twice a day in 1 eye, whereas the other eye was treated with fluorometholone 0.1% (steroid group), 4 times a day for 4 weeks postoperatively. The primary efficacy outcome was the presence of anterior chamber cells and flare at 1 week postoperatively. Anterior chamber cells and flare at 4 to 8 weeks, corrected distance visual acuity, central corneal thickness, conjunctival hyperemia, dry eye parameters, foveal thickness, and ocular and visual discomfort were evaluated as secondary outcomes. Results: At week 1, residual anterior chamber inflammation was not statistically significantly different between the groups (-1.03 ± 1.27 vs -0.95 ± 1.24, P = .4850). However, the NSAID group recovered from conjunctival hyperemia more rapidly than the steroid group (0.30 ± 0.52 vs 0.44 ± 0.81, P = .0144 at week 1). The increase in central corneal thickness in the NSAID group was less than that in the steroid group 1 week postoperatively (7.87 ± 22.46 vs 29.47 ± 46.60 μm, P < .0001). The change in foveal thickness in the NSAID group was significantly less than that in the steroid group (18.11 ± 68.19 vs 22.25 ± 42.37 μm, P = .0002). Lower levels of postoperative ocular and visual discomfort were reported in the NSAID group than in the steroid group under treatment. Conclusions: Preservative-free bromfenac was as effective as preservative-free fluorometholone eyedrops in anterior chamber inflammation control and showed better signs and symptoms after cataract surgery. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Elsevier Science | - |
dc.relation.isPartOf | JOURNAL OF CATARACT AND REFRACTIVE SURGERY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adrenal Cortex Hormones / therapeutic use | - |
dc.subject.MESH | Anti-Inflammatory Agents, Non-Steroidal / therapeutic use | - |
dc.subject.MESH | Cataract Extraction* | - |
dc.subject.MESH | Cataract* | - |
dc.subject.MESH | Fluorometholone / therapeutic use | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hyperemia* / drug therapy | - |
dc.subject.MESH | Inflammation / drug therapy | - |
dc.subject.MESH | Ophthalmic Solutions | - |
dc.subject.MESH | Phacoemulsification* | - |
dc.subject.MESH | Postoperative Complications / drug therapy | - |
dc.subject.MESH | Preservatives, Pharmaceutical / therapeutic use | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Comparison of a preservative-free nonsteroidal anti-inflammatory drug and preservative-free corticosteroid after uneventful cataract surgery: multicenter, randomized, evaluator-blinded clinical trial | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Ophthalmology (안과학교실) | - |
dc.contributor.googleauthor | Seonjoo Kim | - |
dc.contributor.googleauthor | Byung-Yi Ko | - |
dc.contributor.googleauthor | Jae Woong Koh | - |
dc.contributor.googleauthor | Eun Chul Kim | - |
dc.contributor.googleauthor | Hong Kyun Kim | - |
dc.contributor.googleauthor | Young Joo Shin | - |
dc.contributor.googleauthor | Jong-Suk Song | - |
dc.contributor.googleauthor | Do Hyung Lee | - |
dc.contributor.googleauthor | Ji Eun Lee | - |
dc.contributor.googleauthor | Hyung Keun Lee | - |
dc.contributor.googleauthor | So-Hyang Chung | - |
dc.contributor.googleauthor | Hyun Seung Kim | - |
dc.identifier.doi | 10.1097/j.jcrs.0000000000000841 | - |
dc.contributor.localId | A03303 | - |
dc.relation.journalcode | J01299 | - |
dc.identifier.eissn | 1873-4502 | - |
dc.identifier.pmid | 34629379 | - |
dc.contributor.alternativeName | Lee, Hyung Keun | - |
dc.contributor.affiliatedAuthor | 이형근 | - |
dc.citation.volume | 48 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 710 | - |
dc.citation.endPage | 716 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CATARACT AND REFRACTIVE SURGERY, Vol.48(6) : 710-716, 2022-06 | - |
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