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Baseline characteristics of participants enrolled in the KoreaN cohort study for Outcomes in patients With Pediatric Chronic Kidney Disease (KNOW-Ped CKD)

Authors
 Peong Gang Park  ;  Hee Gyung Kang  ;  Eujin Park  ;  Yo Han Ahn  ;  Hyun Jin Choi  ;  Kyoung Hee Han  ;  Seong Heon Kim  ;  Heeyeon Cho  ;  Keum Hwa Lee  ;  Jae Il Shin  ;  Min Hyun Cho  ;  Joo Hoon Lee  ;  Young Seo Park  ;  Jayoun Kim  ;  Il-Soo Ha 
Citation
 PEDIATRIC NEPHROLOGY, Vol.37(12) : 3177-3187, 2022-12 
Journal Title
PEDIATRIC NEPHROLOGY
ISSN
 0931-041X 
Issue Date
2022-12
MeSH
Child ; Cohort Studies ; Cross-Sectional Studies ; Disease Progression ; Female ; Glomerular Filtration Rate ; Humans ; Kidney ; Male ; Renal Insufficiency, Chronic* / epidemiology ; Renal Insufficiency, Chronic* / etiology ; Risk Factors
Keywords
Baseline characteristics ; Chronic kidney disease ; Cohort ; KNOW-Ped CKD
Abstract
Background: We developed the KoreaN cohort study for Outcomes in patients With Pediatric Chronic Kidney Disease (KNOW-Ped CKD) as a subcohort of KNOW-CKD to investigate the different characteristics of pediatric CKD between countries and races.

Methods: Children aged younger than 18 years with stage 1 ~ 5 CKD were recruited at seven major pediatric nephrology centers in Korea. Blood and urine samples, as well as demographic and clinical data, were collected. From 2011 to 2016, 458 children were enrolled, and the baseline profiles of 437 children were analyzed.

Results: The median age of the cohort was 10.9 years old, and 68.0% were males. The median estimated glomerular filtration rate was 53.1 mL/min/1.73 m2. The most common etiology of CKD was congenital anomalies of the kidney and urinary tract (42.6%), followed by glomerulopathies (25.6%).

Conclusion: We report a cross-sectional analysis of the overall baseline characteristics such as age, CKD stage, and underlying kidney disease of the KNOW-Ped CKD. The cohort will be longitudinally followed for ten years. "A higher resolution version of the Graphical abstract is available as Supplementary information."
Full Text
https://link.springer.com/article/10.1007/s00467-021-05278-3
DOI
10.1007/s00467-021-05278-3
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Shin, Jae Il(신재일) ORCID logo https://orcid.org/0000-0003-2326-1820
Lee, Keum Hwa(이금화) ORCID logo https://orcid.org/0000-0002-1511-9587
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/194370
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