Cited 6 times in
A chimeric thermostable M2e and H3 stalk-based universal influenza A virus vaccine
DC Field | Value | Language |
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dc.contributor.author | 성백린 | - |
dc.date.accessioned | 2023-06-02T00:37:08Z | - |
dc.date.available | 2023-06-02T00:37:08Z | - |
dc.date.issued | 2022-06 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/194310 | - |
dc.description.abstract | We developed a new chimeric M2e and H3 hemagglutinin (HA) stalk protein vaccine (M2e-H3 stalk) by genetic engineering of modified H3 stalk domain conjugated with conserved M2e epitopes to overcome the drawbacks of low efficacy by monomeric domain-based universal vaccines. M2e-H3 stalk protein expressed and purified from Escherichia coli was thermostable, displaying native-like antigenic epitopes recognized by antisera of different HA subtype proteins and influenza A virus infections. Adjuvanted M2e-H3 stalk vaccination induced M2e and stalk-specific IgG antibodies recognizing viral antigens on virus particles and on the infected cell surface, CD4+ and CD8+ T-cell responses, and antibody-dependent cytotoxic cell surrogate activity in mice. M2e-H3 stalk was found to confer protection against heterologous and heterosubtypic cross-group subtype viruses (H1N1, H5N1, H9N2, H3N2, H7N9) at similar levels in adult and aged mice. These results provide evidence that M2e-H3 stalk chimeric proteins can be developed as a universal influenza A virus vaccine candidate for young and aged populations. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | NPJ VACCINES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | A chimeric thermostable M2e and H3 stalk-based universal influenza A virus vaccine | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Microbiology (미생물학교실) | - |
dc.contributor.googleauthor | Jeeva Subbiah | - |
dc.contributor.googleauthor | Judy Oh | - |
dc.contributor.googleauthor | Ki-Hye Kim | - |
dc.contributor.googleauthor | Chong-Hyun Shin | - |
dc.contributor.googleauthor | Bo Ryoung Park | - |
dc.contributor.googleauthor | Noopur Bhatnagar | - |
dc.contributor.googleauthor | Baik-Lin Seong | - |
dc.contributor.googleauthor | Bao-Zhong Wang | - |
dc.contributor.googleauthor | Sang-Moo Kang | - |
dc.identifier.doi | 10.1038/s41541-022-00498-6 | - |
dc.contributor.localId | A06211 | - |
dc.relation.journalcode | J04443 | - |
dc.identifier.pmid | 35768475 | - |
dc.contributor.alternativeName | Seong, Baik L | - |
dc.contributor.affiliatedAuthor | 성백린 | - |
dc.citation.volume | 7 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 68 | - |
dc.identifier.bibliographicCitation | NPJ VACCINES, Vol.7(1) : 68, 2022-06 | - |
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