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Global burden of primary liver cancer and its association with underlying aetiologies, sociodemographic status, and sex differences from 1990-2019: A DALY-based analysis of the Global Burden of Disease 2019 study

 Sungchul Choi  ;  Beom Kyung Kim  ;  Dong Keon Yon  ;  Seung Won Lee  ;  Han Gyeol Lee  ;  Ho Hyeok Chang  ;  Seoyeon Park  ;  Ai Koyanagi  ;  Louis Jacob  ;  Elena Dragioti  ;  Joaquim Radua  ;  Jae Il Shin  ;  Seung Up Kim  ;  Lee Smith 
 CLINICAL AND MOLECULAR HEPATOLOGY, Vol.29(2) : 433-452, 2023-04 
Journal Title
Issue Date
Female ; Global Burden of Disease ; Hepatitis C* / complications ; Hepatitis C* / epidemiology ; Humans ; Incidence ; Liver Neoplasms* / epidemiology ; Liver Neoplasms* / etiology ; Male ; Non-alcoholic Fatty Liver Disease* / complications ; Non-alcoholic Fatty Liver Disease* / diagnosis ; Non-alcoholic Fatty Liver Disease* / epidemiology ; Quality-Adjusted Life Years ; Sex Characteristics
Aetiology ; Global burden ; Incidence ; Mortality ; Primary liver cancer
Background/Aims: Global distribution of dominant liver cancer aetiologies has significantly changed over the past decades. This study analyzed the updated temporal trends of liver cancer aetiologies and sociodemographic status in 204 countries and territories from 1990 to 2019.

Methods: The Global Burden of Disease 2019 report was used for statistical analysis. In addition, we performed stratification analysis to five quintiles using sociodemographic index and 21 geographic regions.

Results: The crude numbers of liver cancer disease-adjusted life years (DALYs) and deaths significantly increased during the study period (DALYs; 11,278,630 in 1990 and 12,528,422 in 2019, deaths; 365,215 in 1990 and 484,577 in 2019). However, the Age-standardized DALY and mortality rates decreased. Hepatitis B virus (HBV) remains the leading cause of liver cancer DALYs and mortality, followed by hepatitis C virus (HCV), alcohol consumption, and non-alcoholic steatohepatitis/non-alcoholic fatty liver disease (NASH/NAFLD). Although Age-standardized DALY and mortality rates of liver cancer due to HBV and HCV have decreased, the rates due to alcohol consumption and NASH/NAFLD have increased.

In 2019, the population of the East Asia region had the highest Age-standardized DALY and mortality rates, followed by high-income Asia-Pacific and Central Asia populations. Although East Asia and high-income Asia-Pacific regions showed a decrease during the study period, Age-standardized DALY rates increased in Central Asia. High-income North American and Australasian populations also showed a significant increase in Age-standardized DALY.

Conclusions: Liver cancer remains an ongoing global threat. The burden of liver cancer associated with alcohol consumption and NASH/NAFLD is markedly increasing and projected to continuously increase.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Beom Kyung(김범경) ORCID logo https://orcid.org/0000-0002-5363-2496
Kim, Seung Up(김승업) ORCID logo https://orcid.org/0000-0002-9658-8050
Shin, Jae Il(신재일) ORCID logo https://orcid.org/0000-0003-2326-1820
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