38 77

Cited 0 times in

Clinical characteristics of pediatric patients infected with SARS-CoV-2 versus common human coronaviruses: a national multicenter study

 In Suk Sol  ;  Eun Lee  ;  Hyeon-Jong Yang  ;  Yong Ju Lee  ;  Hye Yung Yum  ;  Mi-Hee Lee  ;  Mi Ae Chu  ;  Hui Jeong Moon  ;  Hyo-Bin Kim  ;  Ju Hee Seo  ;  Jung Yeon Shim  ;  Ji Young Ahn  ;  Yoon Young Jang  ;  Hai Lee Chung  ;  Eun Hee Chung  ;  Kyunghoon Kim  ;  Bong-Seong Kim  ;  Cheol Hong Kim  ;  Yang Park  ;  Meeyong Shin  ;  Kyung Suk Lee  ;  Man Yong Han  ;  Soo-Jong Hong  ;  Eun Kyeong Kang  ;  Chang Keun Kim 
 Clinical and Experimental Pediatrics, Vol.66(3) : 134-141, 2023-03 
Journal Title
Clinical and Experimental Pediatrics
Issue Date
COVID-19 ; Child ; Coronavirus ; SARS-CoV-2
COVID-19 ; Child ; Coronavirus ; SARS-CoV-2
Background: Human coronaviruses (HCoV) cause mild upper respiratory infections; however, in 2019, a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged, causing an acute respiratory disease pandemic. Coronaviruses exhibit marked epidemiological and clinical differences. Purpose: This study compared the clinical, laboratory, and radiographic findings of children infected with SARS-CoV-2 versus HCoV. Methods: SARS-CoV-2 data were obtained from the Korea Disease Control and Prevention Agency (KDCA) registry and 4 dedicated coronavirus disease 2019 (COVID-19) hospitals. Medical records of children admitted with a single HCoV infection from January 2015 to March 2020 were collected from 10 secondary/tertiary hospitals. Clinical data included age, sex, underlying disease, symptoms, test results, imaging findings, treatment, and length of hospital stay. Results: We compared the clinical characteristics of children infected with HCoV (n=475) to those of children infected with SARS-CoV-2 (272 from KDCA, 218 from COVID-19 hospitals). HCoV patients were younger than KDCA patients (older than 9 years:3.6% vs. 75.7%; P<0.001) and patients at COVID-19 hospitals (2.0±2.9 vs 11.3±5.3; P<0.001). Patients with SARS-CoV-2 infection had a lower rate of fever (26.6% vs. 66.7%; P<0.001) and fewer respiratory symptoms than those with HCoV infection. Clinical severity, as determined by oxygen therapy and medication usage, was worse in children with HCoV infection. Children and adolescents with SARS-CoV-2 had less severe symptoms. Conclusion: Children and adolescents with COVID-19 had a milder clinical course and less severe disease than those with HCoV in terms of symptoms at admission, examination find-ings, and laboratory and radiology results. © 2023 by The Korean Pediatric Society.
Files in This Item:
T202302585.pdf Download
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Sol, In Suk(설인숙) ORCID logo https://orcid.org/0000-0003-2470-9682
Lee, Yong Ju(이용주) ORCID logo https://orcid.org/0000-0002-0796-2558
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.