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Differential Expression of NME4 in Trophoblast Stem-Like Cells and Peripheral Blood Mononuclear Cells of Normal Pregnancy and Preeclampsia
DC Field | Value | Language |
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dc.contributor.author | 김영한 | - |
dc.contributor.author | 정윤지 | - |
dc.contributor.author | 조성래 | - |
dc.date.accessioned | 2023-05-31T05:19:26Z | - |
dc.date.available | 2023-05-31T05:19:26Z | - |
dc.date.issued | 2023-04 | - |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/194166 | - |
dc.description.abstract | Preeclampsia (PE) is known to arise from insufficient trophoblast invasion as uterine spiral arteries lack remodeling. A significant reduction in placental perfusion induces an ischemic placental microenvironment due to reduced oxygen delivery to the placenta and fetus, leading to oxidative stress. Mitochondria are involved in the regulation of cellular metabolism and the production of reactive oxygen species (ROS). NME/NM23 nuceloside diphosphate kinase 4 (NME4) gene is known to have the ability to supply nucleotide triphosphate and deoxynucleotide triphosphate for replication and transcription of mitochondria. Our study aimed to investigate changes in NME4 expression in PE using trophoblast stem-like cells (TSLCs) from induced pluripotent stem cells (iPSCs) as a model of early pregnancy and peripheral blood mononuclear cells (PBMNCs) as a model of late preterm pregnancy. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | 대한의학회(The Korean Academy of Medical Sciences) | - |
dc.relation.isPartOf | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Infant, Newborn | - |
dc.subject.MESH | Leukocytes, Mononuclear / metabolism | - |
dc.subject.MESH | Nucleoside Diphosphate Kinase D / metabolism | - |
dc.subject.MESH | Placenta / metabolism | - |
dc.subject.MESH | Pre-Eclampsia* | - |
dc.subject.MESH | Pregnancy | - |
dc.subject.MESH | Reactive Oxygen Species / metabolism | - |
dc.subject.MESH | Trophoblasts* / metabolism | - |
dc.subject.MESH | Tumor Suppressor Protein p53 / metabolism | - |
dc.title | Differential Expression of NME4 in Trophoblast Stem-Like Cells and Peripheral Blood Mononuclear Cells of Normal Pregnancy and Preeclampsia | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Obstetrics and Gynecology (산부인과학교실) | - |
dc.contributor.googleauthor | Ji Hea Yu | - |
dc.contributor.googleauthor | Yun Ji Jung | - |
dc.contributor.googleauthor | Myung-Sun Kim | - |
dc.contributor.googleauthor | Sung-Rae Cho | - |
dc.contributor.googleauthor | Young-Han Kim | - |
dc.identifier.doi | 10.3346/jkms.2023.38.e128 | - |
dc.contributor.localId | A00730 | - |
dc.contributor.localId | A04797 | - |
dc.contributor.localId | A03831 | - |
dc.relation.journalcode | J01517 | - |
dc.identifier.eissn | 1598-6357 | - |
dc.identifier.pmid | 37096311 | - |
dc.subject.keyword | Cell Death | - |
dc.subject.keyword | Induced Pluripotent Stem Cells | - |
dc.subject.keyword | Mitochondrial Matrix | - |
dc.subject.keyword | Preeclampsia | - |
dc.subject.keyword | Transcriptome Analysis | - |
dc.subject.keyword | Trophoblast Stem-Like Cells | - |
dc.contributor.alternativeName | Kim, Young Han | - |
dc.contributor.affiliatedAuthor | 김영한 | - |
dc.contributor.affiliatedAuthor | 정윤지 | - |
dc.contributor.affiliatedAuthor | 조성래 | - |
dc.citation.volume | 38 | - |
dc.citation.number | 16 | - |
dc.citation.startPage | e128 | - |
dc.identifier.bibliographicCitation | JOURNAL OF KOREAN MEDICAL SCIENCE, Vol.38(16) : e128, 2023-04 | - |
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