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The prognostic value of comprehensive geriatric assessment on the management of older patients with small cell lung cancer

 You Jin Chun  ;  Kwang Joon Kim  ;  Ji Yeon Lee  ;  Ji Won Choi  ;  Tae Hee Kim  ;  Hye Ryun Kim  ;  Byoung Chul Cho  ;  Min Hee Hong  ;  Chang Oh Kim 
 KOREAN JOURNAL OF INTERNAL MEDICINE, Vol.38(2) : 254-263, 2023-03 
Journal Title
Issue Date
Activities of Daily Living ; Aged ; Geriatric Assessment / methods ; Humans ; Lung Neoplasms* / therapy ; Postural Balance ; Prognosis ; Retrospective Studies ; Small Cell Lung Carcinoma* ; Time and Motion Studies
Frail elderly ; Keywords: Geriatric assessment ; Nutritional status ; Prognosis ; Small cell lung carcinoma
Background/Aims: The prognostic value of a comprehensive geriatric assessment (CGA) for the management of older small cell lung cancer (SCLC) patients remains to be established.

Methods: A retrospective cohort enrolled 21 SCLC patients over 65 years from March 2018 to 2019 at the Yonsei Cancer Center. The CGA included the following instruments: frailty, body mass index, sarcopenia (circumference of arm and calf, Timed Up and Go test, grip strength), comorbidity, polypharmacy, activities of daily living (ADL), Instrumental ADL, nutrition, depression, and cognitive function. The correlations of oncological and geriatric variables with overall survival (OS) were determined.

The log-rank test with Cox model and Kaplan-Meier method were used for the analysis.

Results: The median age was 75 years (range, 67 to 85). All patients had the Eastern Cooperative Oncology Group performance status 0–2. The median survival was 9.93 months (range, 1.53 to 36.30). Among CGA parameters, ADL and nutritional status had significant differences in OS in univariate analysis. In multivariate analysis, only nutritional status was independently associated with survival (hazard ratio, 0.17; 95% confidence interval, 0.05 to 0.57). Median OS for low nutritional status was 5.63 months and the normal nutrition group was 15.5 months (p = 0.004).

Conclusions: Pre-treatment nutritional status measured by CGA appears to be a predictor of OS in older SCLC patients.

However, for further generalization of the implication of CGA in SCLC, a larger scale study with prospective design is strongly needed.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kwang Joon(김광준) ORCID logo https://orcid.org/0000-0002-5554-8255
Kim, Chang Oh(김창오) ORCID logo https://orcid.org/0000-0002-0773-5443
Kim, Hye Ryun(김혜련) ORCID logo https://orcid.org/0000-0002-1842-9070
Lee, Ji Yeon(이지연)
Cho, Byoung Chul(조병철) ORCID logo https://orcid.org/0000-0002-5562-270X
Chun, You Jin(천유진)
Hong, Min Hee(홍민희) ORCID logo https://orcid.org/0000-0003-3490-2195
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