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MECP2 duplication syndrome initially misdiagnosed as cerebral palsy: a case report
DC Field | Value | Language |
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dc.contributor.author | 조성래 | - |
dc.date.accessioned | 2023-04-20T08:22:58Z | - |
dc.date.available | 2023-04-20T08:22:58Z | - |
dc.date.issued | 2023-03 | - |
dc.identifier.issn | 0300-0605 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/194079 | - |
dc.description.abstract | Mutations in the X-linked methyl-CpG-binding protein 2 (MECP2) gene were first described as a cause of Rett syndrome. MECP2 duplication can cause intellectual disability, developmental delay, severe feeding difficulties, and recurrent infections. Here, we report a Korean family with MECP2 duplication syndrome, which was previously misdiagnosed as cerebral palsy. A man in his early 30 s visited our clinic with intellectual disability, speech impairment, epilepsy, and progressive spasticity. He had been previously misdiagnosed with cerebral palsy, and had received orthopedic surgeries such as musculotendinous lengthening and derotational osteotomy. After the surgeries, he received comprehensive rehabilitation. Upon carefully checking his family history, we noted that his younger brother had similar symptoms. Next-generation sequencing revealed whole exon duplication in MECP2 in both the patient and his brother; their mother also had this genetic mutation but was asymptomatic. Early diagnosis is essential for improving the success of MECP2 duplication syndrome treatment. Individuals with MECP2 duplication syndrome should be referred to specialists to manage multidisciplinary symptoms and to regularly check for complications that are common in this syndrome. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Sage Publications | - |
dc.relation.isPartOf | JOURNAL OF INTERNATIONAL MEDICAL RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Cerebral Palsy* / diagnosis | - |
dc.subject.MESH | Cerebral Palsy* / genetics | - |
dc.subject.MESH | Diagnostic Errors | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Intellectual Disability* / genetics | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mental Retardation, X-Linked* / diagnosis | - |
dc.subject.MESH | Mental Retardation, X-Linked* / genetics | - |
dc.subject.MESH | Methyl-CpG-Binding Protein 2 / genetics | - |
dc.title | MECP2 duplication syndrome initially misdiagnosed as cerebral palsy: a case report | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Rehabilitation Medicine (재활의학교실) | - |
dc.contributor.googleauthor | Tae-Yong Kim | - |
dc.contributor.googleauthor | Su-Ji Lee | - |
dc.contributor.googleauthor | Kyung-Min Kim | - |
dc.contributor.googleauthor | Sung-Rae Cho | - |
dc.identifier.doi | 10.1177/03000605231162452 | - |
dc.contributor.localId | A03831 | - |
dc.relation.journalcode | J01462 | - |
dc.identifier.eissn | 1473-2300 | - |
dc.identifier.pmid | 36988314 | - |
dc.subject.keyword | MECP2 duplication syndrome | - |
dc.subject.keyword | Rett syndrome | - |
dc.subject.keyword | cerebral palsy | - |
dc.subject.keyword | differential diagnosis | - |
dc.subject.keyword | neurodevelopmental disorder | - |
dc.subject.keyword | next-generation sequencing | - |
dc.contributor.alternativeName | Cho, Sung Rae | - |
dc.contributor.affiliatedAuthor | 조성래 | - |
dc.citation.volume | 51 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 3000605231162452 | - |
dc.identifier.bibliographicCitation | JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, Vol.51(3) : 3000605231162452, 2023-03 | - |
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