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CTCF controls three-dimensional enhancer network underlying the inflammatory response of bone marrow-derived dendritic cells

Authors
 Bobae Yang  ;  Sueun Kim  ;  Woong-Jae Jung  ;  Kyungwoo Kim  ;  Sugyung Kim  ;  Yong-Jin Kim  ;  Tae-Gyun Kim  ;  Eun-Chong Lee  ;  Jung-Sik Joo  ;  Chae Gyu Park  ;  Sumin Oh  ;  Kyung Hyun Yoo  ;  Hyoung-Pyo Kim 
Citation
 NATURE COMMUNICATIONS, Vol.14(1) : 1277, 2023-03 
Journal Title
NATURE COMMUNICATIONS
Issue Date
2023-03
MeSH
Bone Marrow* ; CCCTC-Binding Factor* ; Chromatin ; Dendritic Cells* ; NF-kappa B* ; Regulatory Sequences, Nucleic Acid
Abstract
Dendritic cells are antigen-presenting cells orchestrating innate and adaptive immunity. The crucial role of transcription factors and histone modifications in the transcriptional regulation of dendritic cells has been extensively studied. However, it is not been well understood whether and how three-dimensional chromatin folding controls gene expression in dendritic cells. Here we demonstrate that activation of bone marrow-derived dendritic cells induces extensive reprogramming of chromatin looping as well as enhancer activity, both of which are implicated in the dynamic changes in gene expression. Interestingly, depletion of CTCF attenuates GM-CSF-mediated JAK2/STAT5 signaling, resulting in defective NF-κB activation. Moreover, CTCF is necessary for establishing NF-κB-dependent chromatin interactions and maximal expression of pro-inflammatory cytokines, which prime Th1 and Th17 cell differentiation. Collectively, our study provides mechanistic insights into how three-dimensional enhancer networks control gene expression during bone marrow-derived dendritic cells activation, and offers an integrative view of the complex activities of CTCF in the inflammatory response of bone marrow-derived dendritic cells.
Files in This Item:
T202301862.pdf Download
DOI
10.1038/s41467-023-36948-5
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Tropica Medicine (열대의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Tae-Gyun(김태균) ORCID logo https://orcid.org/0000-0002-2116-4579
Kim, Hyoung Pyo(김형표) ORCID logo https://orcid.org/0000-0003-1441-8822
Park, Chae Gyu(박채규) ORCID logo https://orcid.org/0000-0003-1906-1308
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/194055
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