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Validity of automated audiometry for hearing examination in patients with multidrug-resistant tuberculosis

 Nyilo Purnami  ;  Rian W Palandeng  ;  Soedarsono Soedarsono  ;  Dhany Arifianto  ;  In Seok Moon 
 F1000Research, Vol.10 : 1277, 2022-09 
Journal Title
Issue Date
Aminoglycosides / therapeutic use ; Antitubercular Agents / therapeutic use ; Audiometry / methods ; Cross-Sectional Studies ; Hearing ; Hearing Loss* ; Humans ; Retrospective Studies ; Tuberculosis, Multidrug-Resistant* / diagnosis ; Tuberculosis, Multidrug-Resistant* / drug therapy
audiometry ; multidrug-resistant tuberculosis ; ototoxicity
Background: The objective of this study was to test the validity of automated audiometry as a method of hearing examination in patients with multidrug-resistant tuberculosis. Method s: This was a cross-sectional comparative study with a retrospective approach, using patient medical records. Patients with multidrug-resistant tuberculosis (MDR-TB) were recruited based-on medical records that met the inclusion and exclusion criteria at the Pulmonology outpatient unit, then referred to the Otorhinolaryngology outpatient unit of the Dr. Soetomo Academic Medical Center. The subjects' hearing function was measured with two different devices (automated audiometer and conventional audiometer) before being given anti-tuberculosis drug therapy (aminoglycoside injection) as ototoxicity monitoring from July to December 2019 period. Sensitivity and specificity analysis was used to assess the validity of the test. Results: A total of 36 patients (72 ears) were included. The comparison test results using the Mann-Whitney test showed that there were significant differences between automated audiometry and conventional audiometry in both ears. Analysis values were: sensitivity 80-97%, specificity 37-96%, positive predictive value 74-98%, and negative predictive value 59-96%. Conclusion s: Automated audiometry is valid for use as a method of hearing examination and monitoring in patients with multidrug-resistant tuberculosis.
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1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
Yonsei Authors
Moon, In Seok(문인석) ORCID logo https://orcid.org/0000-0002-3951-5074
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