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파제트병과 감별이 필요한 Toker 세포 과증식이 동반된 Zuska병 1예

Other Titles
 Toker Cell Hyperplasia in Zuska’s Disease Mimicking Paget’s Disease: A Case Report 
 장윤경  ;  최성은  ;  김지희  ;  김수찬  ;  이희정  ;  김동현  ;  윤문수  ;  신정우 
 Korean Journal of Dermatology (대한피부과학회지), Vol.60(8) : 527-531, 2022-08 
Journal Title
Korean Journal of Dermatology(대한피부과학회지)
Issue Date
Paget's disease ; Toker cell ; Zuska’s disease
Toker cells are epithelial cells, consisting of pale cytoplasm with a polygonal or oval shape. They are found in 10% of the nipple epidermis and require differentiation from Paget cells. However, the Toker cell hyperplasia observed in Zuska’s disease can be difficult to distinguish from Paget cells. In this case report, a 17-year-old girl presented with recurrent erythematous erosion of the right areola. Biopsy specimens showed numerous large epidermal cells with abundant pale cytoplasm. Immunohistochemical staining for CK7 and estrogen receptor were positive, whereas that of HER2/NEU and Ki-67 were negative. Breast ultrasonography showed signs of abscesses and fistulas without suspicious findings of underlying breast cancer. Based on these findings, the patient was diagnosed with Zuska’s disease with Toker cell hyperplasia. Herein, we report a case of Toker cell hyperplasia in Zuska’s disease, thereby highlighting the need to differentiate Toker cells from Paget cells based on clinical, histological, and immunohistochemical characteristics.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Soo Chan(김수찬) ORCID logo https://orcid.org/0000-0002-2327-4755
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