파제트병과 감별이 필요한 Toker 세포 과증식이 동반된 Zuska병 1예

Abstract

Toker cells are epithelial cells, consisting of pale cytoplasm with a polygonal or oval shape. They are found in 10%of the nipple epidermis and require differentiation from Paget cells. However, the Toker cell hyperplasia observedin Zuska’s disease can be difficult to distinguish from Paget cells. In this case report, a 17-year-old girl presentedwith recurrent erythematous erosion of the right areola. Biopsy specimens showed numerous large epidermal cellswith abundant pale cytoplasm. Immunohistochemical staining for CK7 and estrogen receptor were positive, whereasthat of HER2/NEU and Ki-67 were negative. Breast ultrasonography showed signs of abscesses and fistulas withoutsuspicious findings of underlying breast cancer. Based on these findings, the patient was diagnosed with Zuska’sdisease with Toker cell hyperplasia. Herein, we report a case of Toker cell hyperplasia in Zuska’s disease, therebyhighlighting the need to differentiate Toker cells from Paget cells based on clinical, histological, and immunohistochemical characteristics.