54 85

Cited 0 times in

약물유전자검사 결과 해석의 임상검사실 적용 권고안

Other Titles
 Recommendations for Clinical Application of Pharmacogenetic Test Results Interpretation by Clinical Laboratories 
 임정훈  ;  김지은  ;  조선미 
 Laboratory Medicine Online, Vol.12(4) : 244-261, 2022-08 
Journal Title
Laboratory Medicine Online
Issue Date
Pharmacogenetics ; Pharmacogenomic variants ; Practice guideline
As various clinical genetic tests become widely available, the quality of clinical practice in several medical fields, including clinical pharmacogenetics, can be dramatically improved based on genetic test results. Importantly, standardization and the appropriate result interpretation of pharmacogenetic tests are crucial steps toward successful clinical implementation. Among various guidelines published to support accurate clinical decisions, the most commonly utilized evidence is systematically organized in the Clinical Pharmacogenetics Implementation Consortium guidelines, which are regularly updated. The establishment of accurate evidence for each drug-gene pair in pharmacogenetic test result interpretation is essential, but is a complicated and challenging issue. Herein, we provide up-to-date evidence for preparing professional interpretative comments in clinical pharmacogenetic test reports. We provide therapeutic recommendations based on pharmacological genotype-phenotype annotations for a total of 32 drug-gene pairs with sufficient clinical evidence. This document aims to provide reliable evidence and practical information for pharmacogenetic variant interpretation in routine clinical settings, to maximize the efficacy and minimize the side-effects of various pharmacotherapies.
Files in This Item:
T9992022953.pdf Download
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Rim, John Hoon(임정훈) ORCID logo https://orcid.org/0000-0001-6825-8479
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.