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A Mixed-Lipid Diet (Medium-Chain and Long-Chain Triglycerides) for Better Tolerability and Efficiency in Pediatric Epilepsy Patients

Authors
 Rita Yu  ;  Eun Joo Lee  ;  Joon Soo Lee  ;  Hoon-Chul Kang  ;  Heung Dong Ki 
Citation
 Annals of Child Neurology, Vol.30(4) : 164-172, 2022-06 
Journal Title
Annals of Child Neurology
ISSN
 2035-909X 
Issue Date
2022-06
Keywords
Diet, ketogenic ; Triglycerides ; Child ; Drug resistant epilepsy
Abstract
Purpose
In the past, the use of medium-chain triglycerides (MCTs) for a ketogenic diet (KD) was expected to improve both patients’ and caregivers’ adherence to treatment, but many gastrointestinal problems have been reported. Through a calculated partial administration of MCTs in a KD, we aimed to reduce these complications, while maintaining acceptable seizure reduction.
Methods
At a tertiary referral center for pediatric patients with epilepsy, MCT oil was given in a 1:1 ratio with long-chain triglycerides to patients on KDs. Patients who began the diet from February 2019 to February 2020 were reviewed retrospectively, and 47 patients with at least 3 months of follow-up records were enrolled in the study
Results
Overall, 29.8% of patients on a KD with an adjusted MCT ratio experienced complications, such as gastrointestinal symptoms and behavioral food refusal, compared to 63.0% of prior KD patients. The mean seizure reduction rate was 68.45%±40.61%, which was not significantly different from the comparison group’s rate of 64.84%±34.24%.
Conclusion
Adjusted MCT incorporation into a KD showed comparable seizure control results, with better tolerability of the diet.
Files in This Item:
T9992022743.pdf Download
DOI
10.26815/acn.2022.00094
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Hoon Chul(강훈철) ORCID logo https://orcid.org/0000-0002-3659-8847
Kim, Heung Dong(김흥동) ORCID logo https://orcid.org/0000-0002-8031-7336
Yu, Rita(유리타미영)
Lee, Joon Soo(이준수) ORCID logo https://orcid.org/0000-0001-9036-9343
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/193799
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