78 116

Cited 0 times in

Suggestions for Escaping the Dark Ages for Pediatric Diffuse Intrinsic Pontine Glioma Treated with Radiotherapy: Analysis of Prognostic Factors from the National Multicenter Study

 Hyun Ju Kim  ;  Joo Ho Lee  ;  Youngkyong Kim  ;  Do Hoon Lim  ;  Shin-Hyung Park  ;  Seung Do Ahn  ;  In Ah Kim  ;  Jung Ho Im  ;  Jae Wook Chung  ;  Joo-Young Kim  ;  Il Han Kim  ;  Hong In Yoon  ;  Chang-Ok Suh 
 CANCER RESEARCH AND TREATMENT, Vol.55(1) : 41-49, 2023-01 
Journal Title
Issue Date
Brain Stem Neoplasms* / diagnosis ; Brain Stem Neoplasms* / pathology ; Brain Stem Neoplasms* / radiotherapy ; Child ; Diffuse Intrinsic Pontine Glioma* ; Glioma* / pathology ; Humans ; Prognosis ; Retrospective Studies
Diffuse intrinsic pontine glioma ; Prognosis ; Radiotherapy
Purpose: This multicenter retrospective study aimed to investigate clinical, radiologic, and treatment-related factors affecting survival in patients with newly diagnosed diffuse intrinsic pontine glioma (DIPG) treated with radiotherapy.

Materials and methods: Patients aged <30 years who underwent radiotherapy as an initial treatment for DIPG between 2000 and 2018 were included; patients who did not undergo magnetic resonance imaging at diagnosis and those with pathologically diagnosed grade I glioma were excluded. We examined medical records of 162 patients collected from 10 participating centers in Korea. The patients' clinical, radiological, molecular, and histopathologic characteristics, and treatment responses were evaluated to identify the prognosticators for DIPG and estimate survival outcomes.

Results: The median follow-up period was 10.8 months (interquartile range, 7.5 to 18.1). The 1- and 2-year overall survival (OS) rates were 53.5% and 19.0%, respectively, with a median OS of 13.1 months. Long-term survival rate (≥ 2 years) was 16.7%, and median OS was 43.6 months. Age (< 10 years), poor performance status, treatment before 2010, and post-radiotherapy necrosis were independently associated with poor OS in multivariate analysis. In patients with increased post-radiotherapy necrosis, the median OS estimates were 13.3 months and 11.4 months with and without bevacizumab, respectively (p=0.138).

Conclusion: Therapeutic strategy for DIPG has remained unchanged over time, and the associated prognosis remains poor. Our findings suggest that appropriate efforts are needed to reduce the occurrence of post-radiotherapy necrosis. Further well-designed clinical trials are recommended to improve the poor prognosis observed in DIPG patients.
Files in This Item:
T202301769.pdf Download
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
Yonsei Authors
Yoon, Hong In(윤홍인) ORCID logo https://orcid.org/0000-0002-2106-6856
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.