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Clinical implications of young-onset pancreatic cancer patients after curative resection in Korea: a Korea Tumor Registry System Biliary Pancreas database analysis

Authors
 Hyung S. Kim  ;  Ho-Seong Han  ;  Woojin Kim  ;  Changsoo Kim  ;  Jin-Young Jang  ;  Wooil Kwon  ;  Jin S. Heo  ;  Sang H. Shin  ;  Ho K. Hwang  ;  Joon S. Park 
Citation
 HPB, Vol.25(1) : 146-154, 2023-01 
Journal Title
HPB
ISSN
 1365-182X 
Issue Date
2023-01
Abstract
Introduction
This study evaluated the clinical characteristics and survival rate after curative resection of young age pancreatic cancer patients using Korea Tumor Registry System Biliary Pancreas (KOTUS-BP) Database analysis.

Methods
We compared demographics and clinical outcomes in patients under the age of 50 years (young age group) and those over the age of 65 years (standard group) between 1991 and 2017. We estimated the survival curve using the Kaplan–Meier method and the hazard ratio using the Cox proportional hazard model and 1:4 propensity matching analysis.

Results
A total of 2470 patients were analyzed, including 2091 in the standard group and 379 in the young age group. Survival analysis showed a better overall survival in the recently enrolled patients (2011–2017) in both the young age and standard groups (p = 0.001 and p = 0.005, respectively). Between 2011 and 2017, recurrence-free survival was shorter in the young age group (p = 0.02), but the overall survival was not significantly different between the two groups (p = 0.94).

Conclusions
Young-onset pancreatic cancer patients had more advanced stages at the time of diagnosis; however, the overall survival of both the young age and standard groups was similar due to adjuvant treatment after operation.
Full Text
https://www.sciencedirect.com/science/article/abs/pii/S1365182X22016124
DOI
10.1016/j.hpb.2022.10.005
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Woojin(김우진) ORCID logo https://orcid.org/0000-0001-5520-4228
Kim, Chang Soo(김창수) ORCID logo https://orcid.org/0000-0002-5940-5649
Kim, Hyung Sun(김형선) ORCID logo https://orcid.org/0000-0002-9002-3569
Park, Joon Seong(박준성) ORCID logo https://orcid.org/0000-0001-8048-9990
Hwang, Ho Kyoung(황호경) ORCID logo https://orcid.org/0000-0003-4064-7776
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/193733
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