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Impact of iron status on kidney outcomes in kidney transplant recipients

 Hyo Jeong Kim  ;  Ro Han  ;  Kyung Pyo Kang  ;  Jung-Hwa Ryu  ;  Myung-Gyu Kim  ;  Kyu Ha Huh  ;  Jae Berm Park  ;  Chan-Duck Kim  ;  Seungyeup Han  ;  Hyung Woo Kim  ;  Beom Seok Kim  ;  Jaeseok Yang 
 SCIENTIFIC REPORTS, Vol.13(1) : 861, 2023-01 
Journal Title
Issue Date
Cohort Studies ; Ferritins ; Humans ; Iron* ; Kidney / chemistry ; Kidney Transplantation* / adverse effects ; Transferrin / analysis
Iron plays an important role in hemodynamics and the immunity, independent of anemia. Since dynamic changes occur in iron storage after kidney transplantation (KT), we investigated the association between iron status and kidney outcomes in KT patients. We analyzed data from the KoreaN cohort study for Outcome in patients With KT (KNOW-KT). The iron status was classified into three groups based on ferritin or transferrin saturation (TSAT) levels one year after KT, with reference ranges of 20‒35% and 100‒300 ng/mL for TSAT and ferritin, respectively. The primary outcome was the composite outcome, which consisted of death, graft failure, and an estimated glomerular filtration rate decline ≥ 50%. In total, 895 patients were included in the final analysis. During a median follow-up of 5.8 years, the primary outcome occurred in 94 patients (19.8/1000 person-years). TSAT levels decreased one year after KT and thereafter gradually increased, whereas ferritin levels were maintained at decreased levels. The adjusted hazard ratios (95% confidence intervals) for the composite outcome were 1.67 (1.00-2.77) and 1.20 (0.60-2.40) in the TSAT > 35% and ferritin > 300 ng/mL groups, respectively. High iron status with high TSAT levels increases the risk of graft failure or kidney functional deterioration after KT.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Beom Seok(김범석) ORCID logo https://orcid.org/0000-0002-5732-2583
Kim, Hyung Woo(김형우) ORCID logo https://orcid.org/0000-0002-6305-452X
Kim, Hyo Jeong(김효정)
Yang, Jaeseok(양재석)
Huh, Kyu Ha(허규하) ORCID logo https://orcid.org/0000-0003-1364-6989
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