Cited 4 times in
Functional expression of oxytocin receptors in pulp-dentin complex
DC Field | Value | Language |
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dc.contributor.author | 김도현 | - |
dc.date.accessioned | 2023-03-22T02:22:35Z | - |
dc.date.available | 2023-03-22T02:22:35Z | - |
dc.date.issued | 2023-02 | - |
dc.identifier.issn | 0142-9612 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/193583 | - |
dc.description.abstract | Dental pulp-derived stromal cells (DPSCs) are a crucial cell population for maintaining the tissue integrity of the pulp-dentin complex. The oxytocin receptor (OXTR), a member of the G protein-coupled receptor (GPCR) superfamily, plays versatile roles in diverse biological contexts. However, the role of OXTR in dental pulp has not yet been fully understood. Here, we demonstrate the biological functions and significance of OXTR in DPSCs through a multidisciplinary approach. Microarray data of 494 GPCR genes revealed high OXTR expression in human DPSCs (hDPSCs). Blocking OXTR activity increased the expression of osteogenic and odontogenic marker genes, promoting hDPSC differentiation. Additionally, we found that OXTR is involved in extracellular matrix (ECM) remodeling through the regulation of the gene expression related to ECM homeostasis. We further demonstrated that these genetic changes are mediated by trascriptional activity of Yes-associated protein (YAP). Based on the results, a preclinical experiment was performed using an animal model, demonstrating that the application of an OXTR inhibitor to damaged pulp induced significant hard tissue formation. These results provide new insight into the oxytocin-OXTR system in the regenerative process of pulp-dentin complex. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier Science | - |
dc.relation.isPartOf | BIOMATERIALS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Cell Differentiation / physiology | - |
dc.subject.MESH | Cell Proliferation | - |
dc.subject.MESH | Cells, Cultured | - |
dc.subject.MESH | Dental Pulp | - |
dc.subject.MESH | Dentin / physiology | - |
dc.subject.MESH | Extracellular Matrix | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Proteins / metabolism | - |
dc.subject.MESH | Receptors, Oxytocin* / genetics | - |
dc.subject.MESH | Receptors, Oxytocin* / metabolism | - |
dc.subject.MESH | Stem Cells* | - |
dc.title | Functional expression of oxytocin receptors in pulp-dentin complex | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Dept. of Conservative Dentistry (보존과학교실) | - |
dc.contributor.googleauthor | Ju Won Jung | - |
dc.contributor.googleauthor | So Young Park | - |
dc.contributor.googleauthor | Eun Jin Seo | - |
dc.contributor.googleauthor | Il Ho Jang | - |
dc.contributor.googleauthor | Yeji Park | - |
dc.contributor.googleauthor | Dasun Lee | - |
dc.contributor.googleauthor | Dohyun Kim | - |
dc.contributor.googleauthor | Jin Man Kim | - |
dc.identifier.doi | 10.1016/j.biomaterials.2022.121977 | - |
dc.contributor.localId | A00389 | - |
dc.relation.journalcode | J00312 | - |
dc.identifier.eissn | 1878-5905 | - |
dc.identifier.pmid | 36580714 | - |
dc.identifier.url | https://www.clinicalkey.com/#!/content/playContent/1-s2.0-S0142961222006172 | - |
dc.subject.keyword | Dental pulp-derived stromal cells | - |
dc.subject.keyword | Oxytocin receptor | - |
dc.subject.keyword | Pulp-dentin complex | - |
dc.subject.keyword | Yes-associated protein (YAP) | - |
dc.contributor.alternativeName | Kim, Dohyun | - |
dc.contributor.affiliatedAuthor | 김도현 | - |
dc.citation.volume | 293 | - |
dc.citation.startPage | 121977 | - |
dc.identifier.bibliographicCitation | BIOMATERIALS, Vol.293 : 121977, 2023-02 | - |
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